Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels

Camargo, Antonio; Rangel‐Zúñiga, Oriol A.; Haro, Carmen; Meza-Miranda, Eliana Romina; Peña-Orihuela, Patricia J.; Meneses, María E; Marı́n, Carmen; Yubero‐Serrano, Elena M.; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Fernández‐Real, José Manuel; Castro, M.D. Luque de; Tinahones, Francisco J.; López‐Miranda, José; Pérez-Jiménez, Francisco

doi:10.1016/j.foodchem.2014.04.047

Cited by 53 publications

(37 citation statements)

References 71 publications

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“…It has been showed that high levels of total cholesterol and LDL-cholesterol are cardiovascular risk factors. However, increased level of HDLcholesterol assured anti-inflammatory properties [46]. The present results showed that OTE exhibited a significant decrease in the level of lipid parameters in diabetic rats.…”

Section: Renal Function Testssupporting

confidence: 46%

Hypoglycemic and Hypolipidemic Effects of Phenolic Olive Tree Extract in Streptozotocin Diabetic Rats

Laaboudi

Ghanam

Ghoumari

et al. 2016

Int J Pharm Pharm Sci

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Objective: The aim of the present study was to determine the effects of an olive tree extract with high polyphenols content on blood glucose level and other related parameters in streptozotocin-induced diabetic rats.Methods: Diabetes was induced in rats by intraperitoneal injection of streptozotocin (55 mg/kg bw). 72h after injection, rats with fasting blood glucose higher than 2 g/l were used for the experiments. Olive tree extract was administered for 28 d and blood glucose level was measured every 4 d. Total cholesterol, triglycerides, HDL-cholesterol, creatinine, urea, total protein, uric acid, aspartate aminotransferase and alanine aminotransferase levels, were determined at the end of the experiment.Results: The oral administration of olive tree extract contributes to blood glucose level decreasing in diabetic rats group, which was significantly lower at 4th week compared to the diabetic control rats. Moreover, supplementation by olive tree extract decreased significantly (p<0.05) the values of total cholesterol, triglycerides, HDL-cholesterol, creatinine, urea, total protein, uric acid, aspartate aminotransferase and alanine aminotransferase resulting from damage caused by streptozotocin treatment. Beside this, significant reduce (p<0.05) in heart disease risk ratio was observed for treated group (4.1±0.14) compared to untreated group (7.64±0.36), which was quite similar to normal rats (4.50±0.36). Studied olive tree extract effects were similar to those of glibenclamide, a well-known antidiabetic drug.Conclusion: Results herein obtained reveal the hypoglycemic effect of this olive tree extract, suggesting his potential use as a natural antidiabetic agent.

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Section: Renal Function Testssupporting

confidence: 46%

Hypoglycemic and Hypolipidemic Effects of Phenolic Olive Tree Extract in Streptozotocin Diabetic Rats

Laaboudi

Ghanam

Ghoumari

et al. 2016

Int J Pharm Pharm Sci

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“…In cancer patients this could potentially lead to a down-regulation of COX-2 in tumours and thereby inhibit tumour progression. In other intervention studies the inflammatory markers NF-κB, p65, IKKβ, and IKKα [147] and NF-κB, IL-6 and IL-1β [148] have been down-regulated with olive polyphenols. These studies measured changes after single 40 mL doses of EVOO (containing the olive polyphenols), quantities achievable in an individual's standard diet.…”

Section: Olive Leaf Properties That Protect Against Development Anmentioning

confidence: 99%

Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

et al. 2016

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The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of cardiovascular disease and cancers. The main components of this diet include high intake of fruit, vegetables, red wine, extra virgin olive oil (EVOO) and fish, low intake of dairy and red meat. Olive oil has gained support as a key effector of health benefits and there is evidence that this relates to the polyphenol content. Olive leaf extract (OLE) contains a higher quantity and variety of polyphenols than those found in EVOO. There are also important structural differences between polyphenols from olive leaf and those from olive fruit that may improve the capacity of OLE to enhance health outcomes. Olive polyphenols have been claimed to play an important protective role in cancer and other inflammation-related diseases. Both inflammatory and cancer cell models have shown that olive leaf polyphenols are anti-inflammatory and protect against DNA damage initiated by free radicals. The various bioactive properties of olive leaf polyphenols are a plausible explanation for the inhibition of progression and development of cancers. The pathways and signaling cascades manipulated include the NF-κB inflammatory response and the oxidative stress response, but the effects of these bioactive components may also result from their action as a phytoestrogen. Due to the similar structure of the olive polyphenols to oestrogens, these have been hypothesized to interact with oestrogen receptors, thereby reducing the prevalence and progression of hormone related cancers. Evidence for the protective effect of olive polyphenols for cancer in humans remains anecdotal and clinical trials are required to substantiate these claims idea. This review aims to amalgamate the current literature regarding bioavailability and mechanisms involved in the potential anti-cancer action of olive leaf polyphenols.

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“…Camargo et al, 2014, conducted a crossover postprandial trial consisting of the consumption of different phenol contents in virgin olive oilbased breakfasts (high, moderate and low) after a carbohydrate rich (CHO) diet for 6 weeks in 49 participants with metabolic syndrome. They concluded that some genes such as Interleukin-6 (IL6), Interleukin-1 beta (IL1B) and chemokine (C-X-C motif) ligand 1 (CXCL1) were down-regulated, implying a reduction in the postprandial inflammatory response.…”

Section: Postprandial Inflammatory Response To the Polyphenols Of Olimentioning

confidence: 99%

Cardiovascular risk protection from the Mediterranean diet and olive oil. A transcriptomic update in humans

2016

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SUMMARY: This review highlights the human studies that explore the benefits of the Mediterranean diet and olive oil, based on gene expression analysis. We summarized consistent human transcriptomic studies on cardiovascular risk, based on TMD and olive oil interventions, with real life doses and conditions. A literature review was carried out leading up to February 2016. The results show that the TMD, specially supplemented with virgin olive oil, produces beneficial changes in the transcriptomic response of relevant genes in cardiovascular risk such as CAT, GPX1 and SIRT2. p65 and MCP-1, IL1B, IL6, CXCL1, INF-γ, ARHGAP15 and IL7R, which are involved in inflammation; and ABCA1, SR-B1, PPARBP, PPARα, PPARγ, PPARδ, CD-36 and COX-1, which play an important role in cholesterol efflux. The available data illustrate a transcriptomic effect on atherosclerosis, inflammation and oxidative stress pathways as well as the mentioned genes.KEYWORDS: Cardiovascular; Mediterranean Diet; MUFA; Nutrigenomics; Olive oil; Polyphenols; Transcriptomics RESUMEN: Protección cardiovascular de la dieta mediterránea y el aceite de oliva. Una actua lización de transcriptómica en humanos. Esta revisión resume los estudios de transcriptómica en humanos que muestran efectos beneficiosos de la dieta mediterránea tradicional (TMD) y el aceite de oliva, en condiciones y dosis de la vida real en relación al riesgo cardiovascular. La revisión se llevó a cabo hasta febrero de 2016. Los resultados muestran que la TMD, especialmente suplementada con aceite de oliva virgen, ejerce cambios beneficiosos en la respuesta transcriptómica de genes relevantes en el riesgo cardiovascular tales como CAT, GPX1 y SIRT2. p65 y MCP-1, IL1B, IL6, CXCL1, INF-γ, ARHGAP15 y IL7R implicados en la inflamación. ABCA1, SR-B1, PPARBP, PPARα, PPARγ, PPARδ, CD-36 y la COX-1 juegan un papel importante en el eflujo de colesterol. Además, ADRB2 está relacionada con el estrés oxidativo. Los datos disponibles nos llevan a un efecto transcriptómico sobre las vías de arteriosclerosis, inflamación y estrés oxidativo, así como sobre los genes mencionados.

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Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels

Cited by 53 publications

References 71 publications

Hypoglycemic and Hypolipidemic Effects of Phenolic Olive Tree Extract in Streptozotocin Diabetic Rats

Hypoglycemic and Hypolipidemic Effects of Phenolic Olive Tree Extract in Streptozotocin Diabetic Rats

Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

Cardiovascular risk protection from the Mediterranean diet and olive oil. A transcriptomic update in humans

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