Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats

Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice

“…The hot‐plate test is a central antinociceptive test that produces, at constant temperature, two kinds of behavioural response, which are paw‐licking and jumping. Both of these behaviours are considered to be supraspinally integrated responses [36–38] . The present data showed that carvacrol at both doses (50 and 100 mg/kg) increased the reaction time in the hot‐plate test only at 60 min.…”

Olive Leaves Extract Improved Sperm Quality and Antioxidant Status in the Testis of Rat Exposed to Rotenone

“…The obtained powder was mixed with 80% ethanol. The ethanol extract was leached through filter paper and concentrated to dryness under reduced pressure in a rotary evaporator under vacuum and the resulted ethanol extract was frozen (22). Finally, the extract was dissolved in sterile distilled water prior to administration in the animals.…”

Case Series in Patients with Zoster-Associated Pain Using <i>Mangifera indica </i>L. Extract

“…Patients were also excluded if they suffered from active malignancy. The primary outcome measure was the change in the average daily pain score (ADPS) using the Likert scale (baseline week versus final week of study); 0 indicates the absence of pain and 10 indicates unbearable pain [9,14]. The patients individually evaluated the pain that corresponded to the previous 24 h in the morning, and the initial or baseline score consisted in the average of pain daily registered in the week prior to the beginning of the study (enrolment visit).…”

“…In line with this evidence, the use of specific cytokine inhibitors, anti-inflammatory cytokines, immunosuppressive agents, and inhibitors of microglial activation have shown antihyperalgesic effects in neuropathic and inflammatory pain animal models [7]. Many extracts isolated from plants such as Lonicera japonica [8] and Olea europea [9] and isolated compounds such as tanchinone IIA [10], miricetin [11], and mangiferin [12] have also been studied for their antihyperalgesic effects. Another plant that could provide valuable effects in ZAP is the species Mangifera indica Linneo (Mangifera indica L., Anacardiaceae family).…”