Olmesartan/amlodipine: blood pressure lowering and beyond in special populations

Abstract

Clinical studies and population-based analyses show that in patients with hypertension, the majority cannot control their blood pressure (BP) by treatment with a single antihypertensive agent. Combining agents from different antihypertensive classes with complementary modes of action significantly increases efficacy and is a treatment strategy recommended by European treatment guidelines, particularly in patients at high cardiovascular risk. The combinations of antihypertensive agents recommended by the European guidelines include an angiotensin receptor blocker (ARB) with a calcium channel blocker (CCB). The single-pill combination formulation of the ARB olmesartan medoxomil plus the CCB amlodipine is an effective and well-tolerated treatment that provides greater blood pressure lowering and control than the component monotherapies and favours compliance by not increasing pill burden. Importantly, the efficacy and tolerability of olmesartan plus amlodipine is not affected by age, gender, hypertension severity, diabetes status, race or body mass index. Additional blood pressure lowering effects are observed with stepwise uptitration of olmesartan plus amlodipine with or without hydrochlorothiazide, with more patients achieving blood pressure goals. In addition, olmesartan plus amlodipine has demonstrated effects beyond BP lowering by showing beneficial effects on markers of inflammation, endothelial dysfunction and oxidative stress, as well as metabolic improvements and a reduction in new-onset diabetes incidence in hypertensive patients with metabolic syndrome.

A Review of the Efficacy and Tolerability of Combination Amlodipine/Valsartan in Non-White Patients with Hypertension

“…Similar results have been reported with other amlodipine/angiotensin receptor blocker SPC therapies in blacks and Hispanics/Latinos (e.g., amlodipine/olmesartan [75], amlodipine/telmisartan [76]), although data in Asians are lacking with these other combinations. Of note, because of acculturation and certain health behaviors (e.g., diet, physical activity), it is not known whether the literature findings reported in Asian patients can be generalized to the Asian American population.…”

Efficacy and safety of olmesartan medoxomil‑amlodipine besylate tablets (Sevikar®) in older patients with essential hypertension: Subgroup analysis from the Sevikar study

“…Olmesartan medoxomil-amlodipine besylate (OM-AML) tablets are a dose-fixed antihypertensive drug, containing an angiotensin receptor blocker (OM) and a calcium channel blocker (AML) ( 10 , 11 ). Compared with combined administration of OM and AML tablets, dose-fixed OM-AML tablets are more convenient and can promote drug adherence ( 12 ).…”