Olmesartan, an angiotensin II receptor blocker inhibits the progression of cataract formation in cadmium chloride induced hypertensive albino rats

Choudhary, Rajesh; Bodakhe, Surendra H.

doi:10.1016/j.lfs.2016.10.012

Cited by 22 publications

(19 citation statements)

References 42 publications

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“…Losartan may also improve endothelial cell protection and accelerate islet β‐cell regeneration as was suggested by study of Kamper et al (2010) . Our results also exhibited that losartan treatments, orally and topically both considerably reduced the progression of diabetic cataract formation, which was similar to the results of hypertensive cataract, previously reported by Choudhary and Bodakhe (2016) . It is well established that diabetic cataract is mainly associated with polyol pathway, oxidative stress, and osmotic stress, is supported by findings of this study.…”

Section: Discussionsupporting

confidence: 92%

“…[40] Our results also exhibited that losartan treatments, orally and topically both considerably reduced the progression of diabetic cataract formation, which was similar to the results of hypertensive cataract, previously reported by . [41] It is well established that diabetic cataract is mainly associated with polyol pathway, oxidative stress, and osmotic stress, [42][43][44] is supported by findings of this study. We found that losartan and metformin oral treatments reduced the lens AR activity (AR is a NADPH dependent enzyme that converts glucose to sorbitol, in turn leads to increase polyol level), although topical treatment with losartan was found not to affect the AR activity.…”

Section: Effect On Soluble Protein and Insoluble Proteinsupporting

confidence: 83%

“…Modulation of RAS may have excellent outcomes in the prevention of cataract formation. In our previous study, olmesartan and ramipril delayed the progression of hypertension‐associated cataract . Moreover, various studies have experimentally revealed the beneficial effect of captopril and enalapril on cataract in animals .…”

Section: Introductionmentioning

confidence: 87%

“…In our previous study, olmesartan and ramipril delayed the progression of hypertension-associated cataract. [26,27] Moreover, various studies have experimentally revealed the beneficial effect of captopril and enalapril on cataract in animals. [28,29] These data suggested that RAS inhibition may reduce the risk of diabetes-induced cataract formation.…”

mentioning

confidence: 99%

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Losartan delays the progression of streptozotocin‐induced diabetic cataracts in albino rats

Shree

Choudhary

Bodakhe

2019

J Biochem & Molecular Tox

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The ocular renin‐angiotensin system has become an interesting target for ocular diseases because it has been implicated in various ocular diseases such as diabetic retinopathy, glaucoma, age‐related macular degeneration, uveitis, and hypertensive cataracts. In the present study, we explored the effect of topically and orally administered losartan (an angiotensin receptor blocker) on streptozotocin‐induced diabetic cataract in albino rats. Topical treatment with losartan modulated neither the blood glucose level nor the polyol content but oral treatment with losartan decreased both. Topical and oral treatment with losartan significantly increased the antioxidants (glutathione, glutathione peroxidase, superoxide dismutase, and catalase), decreased the lipid peroxidant malondialdehyde, and restored soluble protein, and insoluble protein and various ions (Na+, K+, and Ca2+) in the lens; however, topical treatment had a better effect than oral treatment. These findings demonstrate that topical administration of losartan significantly reduces the risk of cataract formation without affecting either the blood glucose level or polyol contents.

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Section: Discussionsupporting

confidence: 92%

Section: Effect On Soluble Protein and Insoluble Proteinsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 87%

mentioning

confidence: 99%

See 2 more Smart Citations

Losartan delays the progression of streptozotocin‐induced diabetic cataracts in albino rats

Shree

Choudhary

Bodakhe

2019

J Biochem & Molecular Tox

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“…2 Currently, removal of the cataractous lens (By various surgical techniques) followed by intraocular placement of a synthetic lens constitutes the universally-accepted method to manage this condition. 3 Lenticular opacification is postulated as a consequence of oxidative stress. 4 Following photochemical formation of Reactive Oxygen Species (ROS) within the lens and aqueous humour, there is oxidative damage to lenticular tissue.…”

Section: Introductionmentioning

confidence: 99%

A Methanolic Extract of Ocimum basilicum Exhibits Antioxidant Effects and Prevents Selenite-induced Cataract Formation in Cultured Lenses of Wistar Rats

Anand¹,

Sundararajan²,

Anbukkarasi³

et al. 2019

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Objective: An extract (Methanolic) of the Ocimum basilicum leaf was analysed for potential to abrogate experimental formation of cataract in-vitro. Methods: Phytoconstituents were first detected in O. basilicum extracts (Aqueous or methanolic) by gas chromatographic-mass spectrometric analysis. The putative antioxidant activity of these extracts was then assessed by measuring in-vitro radical-scavenging activity, ion-chelating potential and reducing potency. Potential cytotoxicity of the extract on Human lenticular epithelial B3 (HLE-B3) cells was also sought. Finally, possible prevention of cataract formation by the methanolic extract was gauged in selenite-exposed lenses obtained from Wistar rats. There were 3 groups (8 Lenses in each): Group I (Lenses incubated in Dulbecco's modified Eagle's medium [DMEM] alone); Group II (Lenses incubated in DMEM with sodium selenite [100 µM/ml]); Group III (Lenses incubated in DMEM with selenite [100 µM/ml] and the O. basilicum methanolic extract (200 µg/ml DMEM). Gross lenticular morphology was assessed. Levels of lenticular malondialdehyde (MDA) and reduced glutathione (GSH) were also measured. Results: A higher intensity of antioxidative activity was noted in the methanolic extract than in the aqueous extract. The methanolic extract exhibited negligible cytotoxicity. On morphological examination, marked opacification was seen in all 8 Group II lenses whereas there was no opacification in 7 of 8 Group III lenses. Near normal mean levels of reduced glutathione and malondialdehyde, were noted within Group III lenses. Conclusion: The methanolic extract of the O. basilicum leaf appears to prevent selenite-induced cataract formation in-vitro.

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Role of the renin–angiotensin system in the development of cataract formation in angiotensin‐II‐induced experimental rats

Choudhary

Shree

Singh

et al. 2021

J Biochem & Molecular Tox

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Previously, we established several facts regarding hypertension-associated cataractogenesis. As a follow-on study, we evaluated the role of the renin-angiotensin system (RAS) in angiotensin-II (Ang-II)-induced cataract formation in experimental hypertensive rats. Sprague-Dawley male albino rats (150-180 g) were used for the present experiment. The animals were divided into four groups, with six animals in each group. During the 12 weeks of the experimental protocol, the normal group received sterile water (1 ml/kg/day, subcutaneously (sc), and the Ang-II control group received angiotensin (1 mg/kg/day) subcutaneously. The ARB (O) group received olmesartan (2 mg/kg/day) orally, and the ARB (T) group received two drops of olmesartan (5 mM) topically on the cornea; concurrently, both groups were treated with Ang-II (1 mg/kg/day, sc) to induce hypertension. Biweekly, the systolic and the diastolic blood pressures were recorded, and the eyes were examined; moreover, cataractogenic parameters, such as oxidative stress markers and protein contents in the lenses, were evaluated after completion of the experimental protocol. Twelve weeks of olmesartan administered, orally or topically, significantly reduced the progression of cataract formation and restored antioxidants, lipid peroxidation, nitrite content, and protein contents in the lenses of the mice in groups O and T, respectively, as compared with those in the Ang-II control group. On the basis of our results, we conclude that the ocular RAS exacerbates the lenticular oxidative stress that may lead to cataract formation. The results showed that the RAS has an independent and important role in cataract formation under hypertensive conditions.

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Olmesartan, an angiotensin II receptor blocker inhibits the progression of cataract formation in cadmium chloride induced hypertensive albino rats

Cited by 22 publications

References 42 publications

Losartan delays the progression of streptozotocin‐induced diabetic cataracts in albino rats

Losartan delays the progression of streptozotocin‐induced diabetic cataracts in albino rats

A Methanolic Extract of Ocimum basilicum Exhibits Antioxidant Effects and Prevents Selenite-induced Cataract Formation in Cultured Lenses of Wistar Rats

Role of the renin–angiotensin system in the development of cataract formation in angiotensin‐II‐induced experimental rats

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