Olprinone decreases elevated concentrations of cytokine-induced neutrophil chemoattractant-1 in septic rats

Miyakawa, Hiroshi; Kira, Shintaro; Okuda, K; Takeshima, Naozumi; Mori, Masakazu; Noguchi, Takayuki

doi:10.1007/s00540-007-0572-4

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…However, a previous study showed that serum MCP-1 levels are raised in septic patients and are even higher in those with severe sepsis ( 31 ) . Also, MCP-1 and CINC-1 were significantly increased in a severe inflammatory reaction as found in thermal injury and caecal ligation and perforation in rats ( 32 , 33 ) . The discrepancies among the studies may have resulted from the time required to take the measurement and the duration and location of these mediators exist in biological fluids.…”

Section: Discussionmentioning

confidence: 86%

Effects of parenteral glutamine supplementation on modulating the immune response in rats undergoing a total gastrectomy

Lin

Chou

Tsou

et al. 2009

BJN

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The present study investigated the effect of parenteral glutamine (Gln) supplementation on cellular adhesion molecule expression and release of chemokines responsible for inflammatory cell recruitment in rats undergoing a total gastrectomy. Normal rats with internal jugular catheters were assigned to one control group and two experimental groups and received total parenteral nutrition (TPN). A total gastrectomy was performed in the experimental groups, whereas the control group received a sham operation (Sham). The TPN solutions were isonitrogenous and identical in nutrient composition except that the Sham group and one of the experimental group received conventional (Conv) TPN solution, whereas the other experimental group received 25 % of the amino acid nitrogen as Gln. Half of the rats in each group were killed 1 or 3 d after surgery or the Sham to examine their immune response. The results showed that the surgery produced higher polymorphonuclear leucocyte CD11b/CD18 expressions, and Gln supplementation lowered CD11b/CD18 expressions compared with the Conv group post-operatively. The levels of monocyte chemotactic protein-1 and macrophage inflammatory protein-2 in peritoneal lavage fluid were higher in the Gln group than those in the Conv group 1 d post-operatively; these chemotactic proteins had returned to the levels comparable with those in the Sham group on post-operative day 3. These results suggest that Gln supplementation attenuated polymorphonuclear leucocyte integrin expression. In addition, Gln-enriched parenteral nutrition induced an earlier more intensive and rapid immune response to injury than the Conv parenteral nutrition after a total gastrectomy.Total gastrectomy: Glutamine: CD11b/CD18: Monocyte chemotactic protein: Macrophage inflammatory protein Gastric cancer is among the top ten causes of cancer-related deaths for both men and women in many countries, especially in Asia. A total gastrectomy is a major abdominal surgical procedure, which is frequently undertaken for malignant gastric diseases and usually causes much stress to patients. For most gastrectomised patients with gastric diseases, preoperative malnutrition often occurs and adequate post-operative oral intake is achieved late (1,2)

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Section: Discussionmentioning

confidence: 86%

Effects of parenteral glutamine supplementation on modulating the immune response in rats undergoing a total gastrectomy

Lin

Chou

Tsou

et al. 2009

BJN

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“…No reports have addressed the role for olprinone in pathophysiology of SCI. Interestingly, olprinone reduces the IR-induced acute renal injury in rats through enhancement of cAMP, inhibition of leukocyte activation [19], and decreasing elevated concentrations of cytokine-induced neutrophil chemoattractant-1 in septic rats [20].…”

Section: Introductionmentioning

confidence: 96%

Olprinone Attenuates the Acute Inflammatory Response and Apoptosis after Spinal Cord Trauma in Mice

et al. 2010

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BackgroundOlprinone hydrochloride is a newly developed compound that selectively inhibits PDE type III and is characterized by several properties, including positive inotropic effects, peripheral vasodilatory effects, and a bronchodilator effect. In clinical settings, olprinone is commonly used to treat congestive cardiac failure, due to its inotropic and vasodilating effects. The mechanism of these cardiac effects is attributed to increased cellular concentrations of cAMP. The aim of the present study was to evaluate the pharmacological action of olprinone on the secondary damage in experimental spinal cord injury (SCI) in mice.Methodology/Principal FindingsTraumatic SCI is characterized by an immediate, irreversible loss of tissue at the lesion site, as well as a secondary expansion of tissue damage over time. Although secondary injury should be preventable, no effective treatment options currently exist for patients with SCI. Spinal cord trauma was induced in mice by the application of vascular clips (force of 24 g) to the dura via a four-level T5–T8 laminectomy. SCI in mice resulted in severe trauma characterized by edema, neutrophil infiltration, and production of inflammatory mediators, tissue damage, apoptosis, and locomotor disturbance. Olprinone treatment (0.2 mg/kg, i.p.) 1 and 6 h after the SCI significantly reduced: (1) the degree of spinal cord inflammation and tissue injury (histological score), (2) neutrophil infiltration (myeloperoxidase activity), (3) nitrotyrosine formation, (4) pro-inflammatory cytokines, (5) NF-κB expression, (6) p-ERK1/2 and p38 expression and (7) apoptosis (TUNEL staining, FAS ligand, Bax and Bcl-2 expression). Moreover, olprinone significantly ameliorated the recovery of hind-limb function (evaluated by motor recovery score).Conclusions/SignificanceTaken together, our results clearly demonstrate that olprinone treatment reduces the development of inflammation and tissue injury associated with spinal cord trauma.

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Olprinone attenuates the development of ischemia/reperfusion injury of the gut

et al. 2010

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Olprinone decreases elevated concentrations of cytokine-induced neutrophil chemoattractant-1 in septic rats

Abstract: Olprinone decreases elevated CINC-1 concentration in the diaphragm under septic conditions. This suggests that olprinone may inhibit neutrophil recruitment to the diaphragm.

Cited by 6 publications

References 22 publications

Effects of parenteral glutamine supplementation on modulating the immune response in rats undergoing a total gastrectomy

Effects of parenteral glutamine supplementation on modulating the immune response in rats undergoing a total gastrectomy

Olprinone Attenuates the Acute Inflammatory Response and Apoptosis after Spinal Cord Trauma in Mice

Olprinone attenuates the development of ischemia/reperfusion injury of the gut

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