2016
DOI: 10.1021/jacs.6b03523
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Olsalazine-Based Metal–Organic Frameworks as Biocompatible Platforms for H2 Adsorption and Drug Delivery

Abstract: The drug olsalazine (H4olz) was employed as a ligand to synthesize a new series of mesoporous metal–organic frameworks that are expanded analogues of the well-known M2(dobdc) materials (dobdc4– = 2,5-dioxido-1,4-benzene­dicarboxylate; M-MOF-74). The M2(olz) frameworks (M = Mg, Fe, Co, Ni, and Zn) exhibit high surface areas with large hexagonal pore apertures that are approximately 27 Å in diameter. Variable temperature H2 adsorption isotherms revealed strong adsorption at the open metal sites, and in situ infr… Show more

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Cited by 181 publications
(118 citation statements)
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“…Every two Eu III ion centers share four deprotonated carboxylate oxygen atoms from four ligands, forming a dual‐core Eu III ion cluster structure (Figure a). For the ligand olz, unlike the coordination mode in MOF‐74 series where both the deprotonated carboxylate oxygen atoms and the hydroxyl groups are coordinated with metal ions,[23a] three deprotonated carboxylate oxygen atoms in the ligand are coordinated with three Eu III ions, while the other one deprotonated carboxylate oxygen atoms remains uncoordinated, and the two hydroxyl groups also remain exposed (Figure b). The Eu‐olz features three‐dimensional structure with micropores along a and c axes (Figure ).…”
Section: Resultsmentioning
confidence: 99%
“…Every two Eu III ion centers share four deprotonated carboxylate oxygen atoms from four ligands, forming a dual‐core Eu III ion cluster structure (Figure a). For the ligand olz, unlike the coordination mode in MOF‐74 series where both the deprotonated carboxylate oxygen atoms and the hydroxyl groups are coordinated with metal ions,[23a] three deprotonated carboxylate oxygen atoms in the ligand are coordinated with three Eu III ions, while the other one deprotonated carboxylate oxygen atoms remains uncoordinated, and the two hydroxyl groups also remain exposed (Figure b). The Eu‐olz features three‐dimensional structure with micropores along a and c axes (Figure ).…”
Section: Resultsmentioning
confidence: 99%
“…The rational design metal-organic coordination polymers (CPs) have received remarkable attention, not only because of their fascinating architectures and topologies but also because of their potential applications as functional materials [3][4][5][6][7][8]. It is well known that topologies of coordination polymers have a significant impact on their physical and chemical properties [9][10][11][12][13].…”
Section: Discussionmentioning
confidence: 99%
“…This allows reducing the amount of nonactive undesirable compounds to be administered at the benefit of an anticipated decrease of toxicity. Numerous active ligands have been proposed to date to produce bioMOFs: peptides (metal peptide frameworks), nucleobases, carbohydrates, porphyrines, as well as some active ingredients . Unfortunately, most of these bioMOFs are still at their initial stages of development and a very few of them have undergone in vivo preclinical evaluation.…”
Section: Toxicity: From In Vitro To In Vivo Evaluationmentioning
confidence: 99%