Omadacycline, Eravacycline, and Tigecycline Express Anti-Mycobacterium abscessus Activity In Vitro

Abstract

The antimicrobial activities of four third-generation tetracycline-class drugs, omadacycline (OMC), eravacycline (ERC), tigecycline (TGC), and sarecycline (SAC), were determined for 193 M. abscessus isolates. The activities of the four drugs at two different temperatures (30°C and 37°C) were also tested.

Management of M. abscessus subsp. abscessus early-onset prosthetic joint infection: Case report and literature review

“…Note that omadacyclin is not available in Europe yet. Still, this class of antibiotics has proven to be a viable option in the treatment of M. abscessus infections [42] . As for surgical interventions, aggressive ones in the early stages of the disease may shorten the course of antimycobacterial therapy and improve infection control rate.…”

Omadacycline powder for research procured from unauthorized commercial vendors may be impure and/or unstable

“…Omadacycline tosylate from MedChemExpress has been used in at least 19 published studies ( 3 ), 6 of which are in ASM journals, 3 specifically in Antimicrobial Agents and Chemotherap y. Upon review of these 19 publications, omadacycline tosylate claims include, but are not limited to, in vitro potency, impact of resistance mechanisms on in vitro activity, and the propensity to select for mutations associated with resistance ( 3 – 10 ). As such, this analysis was performed to understand how the MedChemExpress powder performs when put through the validated, approved analytical methods used for the Paratek drug substance.…”