2018
DOI: 10.5114/ada.2018.77241
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Omalizumab improves forced expiratory volume in 1 second in patients with severe asthma

Abstract: IntroductionAsthma is a multiphenotypic disease, and therapeutic managenment in patients with severe asthma is particulary difficult, with conventional treatment of severe asthma showing poor efficacy.AimTo analyse forced expiratory volume in 1 s (FEV1) following the adminstration of omalizumab.Material and methodsSix patinents (mean age: 50 ±12.6) with severe, uncontrolled asthma according to the GINA guidelines were enrolled in the study.ResultsTreatment with omalizumab increased in all subjects FEV1 by 17.2… Show more

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Cited by 2 publications
(5 citation statements)
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“…La Iniciativa Global para el Asma distingue fenotipos de asma tipo hipo celular, neutrofílico y eosinofílico o también según la respuesta a terapia como controlada, no controlada y parcialmente controlada. De las cuales el asma controlada responde al 15%, asma parcialmente controlada 30 a 37% y asma no controlada 27 a 50% de aquí deriva la mayoría de pacientes con asma grave (10).…”
Section: Materiales Y Métodosunclassified
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“…La Iniciativa Global para el Asma distingue fenotipos de asma tipo hipo celular, neutrofílico y eosinofílico o también según la respuesta a terapia como controlada, no controlada y parcialmente controlada. De las cuales el asma controlada responde al 15%, asma parcialmente controlada 30 a 37% y asma no controlada 27 a 50% de aquí deriva la mayoría de pacientes con asma grave (10).…”
Section: Materiales Y Métodosunclassified
“…Omalizumab provoca la reducción de aproximadamente 97% de IgE libre, factores FcεRI en 96% en la superficie de basófilos, así como la invasión eosinofílica en epitelio respiratorio o esputo (10). Tanto linfocitos B CD4, CD19, CD3, CD8 y linfocitos citotóxicos como supresores de paredes de los bronquios disminuyen (10) (8).…”
Section: Mecanismo De Acciónunclassified
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“…An important aspect of managing these diseases is early diagnosis, which allows for treatment to begin at the most effective time and minimizes the risk of long-term complications [19]. In the context of allergic diseases, key strategies include avoiding allergens and using medications such as antihistamines, corticosteroids, and inhalers to control symptoms [4,[20][21][22]. In some cases, immunotherapy aimed at reducing sensitivity to allergens may be recommended [1,2].…”
Section: Introductionmentioning
confidence: 99%