Omega‐3 essential fatty acid status is improved during nutritional rehabilitation of adolescent girls with eating disorders and weight loss

Swenne, Ingemar; Rosling, Agneta

doi:10.1111/j.1651-2227.2012.02684.x

Cited by 25 publications

(24 citation statements)

References 18 publications

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“…For n-6 PUFAs, we did not identify any significant differences in LA or ARA, but DGLA and OBA were both elevated in AN compared to controls [15]. Langan et al [21], Zak et al [23], and Swenne et al [24] found LA to be lower in AN, whereas Swenne et al [26] and Caspar-Bauguil et al [27] identified decreased ARA in erythrocyte membrane and RBC phospholipid of AN, respectively.…”

Section: Discussionmentioning

confidence: 78%

“…In 2011 and 2012, Swenne et al published 3 related papers [24–26] examining non-fasting plasma phospholipid and erythrocyte membranes (ERY) PUFAs in up to 220 girls with eating disorders and 39 healthy controls [24,25]. The authors also examined changes of ERY PUFAs in 24 ED who had PUFA measured at admission and the 1-year follow-up visit [26].…”

Section: Discussionmentioning

confidence: 99%

“…The authors also examined changes of ERY PUFAs in 24 ED who had PUFA measured at admission and the 1-year follow-up visit [26]. At the baseline assessment visit, 67% of ED subjects were demonstrating a clear weight loss course.…”

Section: Discussionmentioning

confidence: 99%

“…The increase of LC n-3 PUFA in ED patients, however, went above the level of the healthy controls. Studies by Swenne et al show that aberrant PUFA is evident in individuals with ED, and restoration of healthy eating behavior and weight may lead to normalization of PUFA markers [26]. …”

Section: Discussionmentioning

confidence: 99%

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Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa

Shih

Morisseau

et al. 2017

Prostaglandins & Other Lipid Mediators

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Anorexia nervosa (AN) is a complex psychiatric disorder with high morbidity and mortality rates. While many individuals make full recoveries, up to a third of patients develop a chronic, treatment-resistant form of the illness that leads to a premature death in 15–20% of those affected. There have been few advances in treatment, both in terms of psychological or pharmacologic treatment over the last 30 years. Food aversion is commonly cited by patients with AN as a barrier to normalizing eating and weight. Our group has a keen interest in examining factors that might allow this to be addressed, thus improving treatment outcomes through personalized dietary plans or nutritional supplementation related to underlying genetic status. We demonstrated that polyunsaturated fatty acids (PUFAs)-derived bioactive lipids (eicosanoids) are implicated in not only the risk of AN, but also with its comorbid psychopathology. Of interest, the differential postprandial omega 6-derived eicosanoid shift observed in AN highlights the possibility that the metabolism of PUFAs is an important mechanism underlying the profound food version, contributing to pathological food restriction in AN. A concise knowledge of the relationships among PUFAs, eicosanoids, and AN clinical course and psychopathology could be the key to developing personalized nutritional rehabilitative treatments for those suffering from AN. This paper provides a comprehensive overview of the literature on PUFAs in AN. We also selectively reviewed the clinical benefits PUFA treatments exert in other psychiatric diseases, on weight and appetite regulation, and for resolution of inflammation, all of which are relevant in the disease course and outcome of AN. We propose that personalized PUFA formulation be developed and tested as a novel adjunctive treatment for patients with AN. We hypothesize that with personalized PUFA formulation, food aversion and anxiety about eating will decrease while mood, dietary behavior, and weight restoration will improve in AN, leading to improvements in the overall treatment outcome.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa

Shih

Morisseau

et al. 2017

Prostaglandins & Other Lipid Mediators

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“…This Ethyl eicosapentaenoic acid (E-EPA, an omega-3 fatty acid) has been suggested as a treatment for anorexia nervosa (Ayton, et al, 2004). Swenne and Rosling (2012) recently reported that rehabilitated anorexic girls exhibited normal fatty acid profiles.…”

Section: Fatty Acid Profile and Membrane Fluiditymentioning

confidence: 99%

The Role of Essential Fatty Acids in Anorexia Nervosa and Obesity

Yehuda

Rabinovitz

2015

Critical Reviews in Food Science and Nutrition

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The two basic questions in food intake study are what we eat, and how much do we eat. Most research is directed toward the control of how much is eaten. This is likely the result of the increased number of individuals with eating disorders in the Western world. Feeding behavior is highly complex, and is controlled by many psychological, physiological, biochemical, and immunological factors. The aim of this review is to clarify the involvement of fatty acids in eating disorders such as anorexia and binge eating disorder. The review will describe the modified fatty acid profile observed in individuals with anorexia or binge eating disorder, and discuss on what factors fatty acids can exert beneficial effects. In addition, the differences and similarities between anorexia and binge eating disorder will be discussed. We suggest that beneficial effects of essential fatty acids on both anorexia and binge eating disorder can be explained by the stabilizing effect of those fatty acids on the neuronal membrane fluidity index.

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Eating Disorders

Ross

2014

Integrative Weight Management

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Omega‐3 essential fatty acid status is improved during nutritional rehabilitation of adolescent girls with eating disorders and weight loss

Cited by 25 publications

References 18 publications

Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa

Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa

The Role of Essential Fatty Acids in Anorexia Nervosa and Obesity

Eating Disorders

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