Omega 3 Fatty Acid and Skin Diseases

IgA, previously called Henoch-Schönlein vasculitis, is an essential immune component that drives the host immune response to the external environment. As IgA has the unique characteristic of a flexible response to broad types of microorganisms, it sometimes causes an autoreactive response in the host human body. IgA vasculitis and related organ dysfunction are representative IgA-mediated autoimmune diseases; bacterial and viral infections often trigger IgA vasculitis. Recent drug developments and the presence of COVID-19 have revealed that these agents can also trigger IgA vasculitis. These findings provide a novel understanding of the pathogenesis of IgA vasculitis. In this review, we focus on the characteristics of IgA and symptoms of IgA vasculitis and other organ dysfunction. We also mention the therapeutic approach, biomarkers, novel triggers for IgA vasculitis, and epigenetic modifications in patients with IgA vasculitis.

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Section: Treatmentmentioning

confidence: 99%

“…Omega-3 fatty acids are present in fish oils and nuts [ 117 ]. Omega-3 fatty acids and their metabolites have potential anti-inflammatory action in inflammatory skin diseases [ 117 , 118 , 119 , 120 ]. Purpura is not a typical form of inflammatory skin disease, but causes inflammation in the blood vessels.…”

Section: Treatmentmentioning

confidence: 99%

IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes

Sugino

Sawada

Nakamura

2021

IJMS

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“…A fatty acid is a carboxylic acid with a long aliphatic chain, which is either a saturated or unsaturated fatty acid [ 6 ]. Fatty acids are important dietary sources of fuel for animals and are essential structural components for cells.…”

Section: The Daily Lifestyle Associated With the Cutaneous Malignanciesmentioning

confidence: 99%

“…Among these environmental factors on Earth, daily lifestyle is a fundamental part of human life and influences human health. For instance, the influence of lifestyles, such as dietary foods and luxury consumptions, accumulates daily and affects human health [ 4 , 5 , 6 ]. Therefore, these influences are helpful information for clinicians to understand the detailed molecular pathogenesis of daily lifestyle-related human diseases.…”

Section: Introductionmentioning

confidence: 99%

Daily Lifestyle and Cutaneous Malignancies

Sawada

Nakamura

2021

IJMS

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Daily lifestyle is a fundamental part of human life and its influence accumulates daily in the human body. We observe that a good daily lifestyle has a beneficial impact on our health; however, the actual effects of individual daily lifestyle factors on human skin diseases, especially skin cancers, have not been summarized. In this review, we focused on the influence of daily lifestyle on the development of skin cancer and described the detailed molecular mechanisms of the development or regulation of cutaneous malignancies. Several daily lifestyle factors, such as circadian rhythm disruption, smoking, alcohol, fatty acids, dietary fiber, obesity, and ultraviolet light, are known to be associated with the risk of cutaneous malignancies, malignant melanoma, squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma. Although the influence of some daily lifestyles on the risk of skin cancers is controversial, this review provides us a better understanding of the relationship between daily lifestyle factors and skin cancers.

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“…DHA is enriched in the brain at up to 15% of the total fatty acid (FA) pool and has been shown to be essential for neuronal and retinal development and function [ 1 ]. Studies have shown that the consumption of LC omega-3 oil also helps prevent heart disease, neural disorders, arthritis, asthma, and skin diseases in humans [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Docosahexaenoic Acid Is Naturally Concentrated at the sn-2 Position in Triacylglycerols of the Australian Thraustochytrid Aurantiochytrium sp. Strain TC 20

Lee-Chang

Taylor

Drummond³

et al. 2021

Marine Drugs

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The Labyrinthulomycetes or Labyrinthulea are a class of protists that produce a network of filaments that enable the cells to glide along and absorb nutrients. One of the main two Labyrinthulea groups is the thraustochytrids, which are becoming an increasingly recognised and commercially used alternate source of long-chain (LC, ≥C20) omega-3 containing oils. This study demonstrates, to our knowledge for the first time, the regiospecificity of the triacylglycerol (TAG) fraction derived from Australian thraustochytrid Aurantiochytrium sp. strain TC 20 obtained using 13C nuclear magnetic resonance spectroscopy (13C NMR) analysis. The DHA present in the TC 20 TAG fraction was determined to be concentrated in the sn-2 position, with TAG (16:0/22:6/16:0) identified as the main species present. The sn-2 preference is similar to that found in salmon and tuna oil, and differs to seal oil containing largely sn-1,3 LC-PUFA. A higher concentration of sn-2 DHA occurred in the thraustochytrid TC 20 oil compared to that of tuna oil.

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Omega 3 Fatty Acid and Skin Diseases

Cited by 32 publications

References 117 publications

IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes

IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes

Daily Lifestyle and Cutaneous Malignancies

Docosahexaenoic Acid Is Naturally Concentrated at the sn-2 Position in Triacylglycerols of the Australian Thraustochytrid Aurantiochytrium sp. Strain TC 20

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