Omega-3 fatty acid diglyceride emulsions as a novel injectable acute therapeutic in neonatal hypoxic-ischemic brain injury

Zirpoli, Hylde; Bernis, Maria Eugenia; Sabir, Hemmen; Manual Kollareth, Denny Joseph; Hamilton, James A.; Huang, Nasi; Ng, Jesse; Sosunov, Sergey A.; Gaebler, Ben; Ten, Vadim S.; Deckelbaum, Richard J.

doi:10.1016/j.biopha.2024.116749

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.116749

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Omega-3 fatty acid diglyceride emulsions as a novel injectable acute therapeutic in neonatal hypoxic-ischemic brain injury

Hylde Zirpoli,

Maria Eugenia Bernis,

Hemmen Sabir

et al.

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2024

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Cited by 2 publications

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Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids

Alfutaimani,

Alharbi,

S. Alahmari

et al. 2024

International Journal of Pharmaceutics: X

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Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids

Alfutaimani,

Alharbi,

S. Alahmari

et al. 2024

International Journal of Pharmaceutics: X

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Omega-3 Fatty Acids and Traumatic Injury in the Adult and Immature Brain

Valero-Hernandez,

Tremoleda,

Michael-Titus

2024

Nutrients

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Background/Objectives: Traumatic brain injury (TBI) can lead to substantial disability and health loss. Despite its importance and impact worldwide, no treatment options are currently available to help protect or preserve brain structure and function following injury. In this review, we discuss the potential benefits of using omega-3 polyunsaturated fatty acids (O3 PUFAs) as therapeutic agents in the context of TBI in the paediatric and adult populations. Methods: Preclinical and clinical research reports investigating the effects of O3 PUFA-based interventions on the consequences of TBI were retrieved and reviewed, and the evidence presented and discussed. Results: A range of animal models of TBI, types of injury, and O3 PUFA dosing regimens and administration protocols have been used in different strategies to investigate the effects of O3 PUFAs in TBI. Most evidence comes from preclinical studies, with limited clinical data available thus far. Overall, research indicates that high O3 PUFA levels help lessen the harmful effects of TBI by reducing tissue damage and cell loss, decreasing associated neuroinflammation and the immune response, which in turn moderates the severity of the associated neurological dysfunction. Conclusions: Data from the studies reviewed here indicate that O3 PUFAs could substantially alleviate the impact of traumatic injuries in the central nervous system, protect structure and help restore function in both the immature and adult brains.

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Omega-3 fatty acid diglyceride emulsions as a novel injectable acute therapeutic in neonatal hypoxic-ischemic brain injury

Cited by 2 publications

References 70 publications

Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids

Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids

Omega-3 Fatty Acids and Traumatic Injury in the Adult and Immature Brain

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