Omega-3 fatty acid ethyl esters increase heart rate variability in patients with coronary disease

Villa, Barbara; Calabresi, Laura; Chiesa, Giulia; Risé, Patrizia; Galli, Cláudio; Sirtori, Cesare R.

doi:10.1006/phrs.2002.0989

Cited by 74 publications

(55 citation statements)

References 12 publications

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“…seasons, respectively. The presence of higher compositional ratio of PUFA in leaves suggests their higher health beneficial effects, as PUFA may decrease blood cholesterol levels (Hargrove et al, 2001) and improve HDL fluidity (Villa et al, 2002). Furthermore, leaves also exhibited lowest cultivar dependent variation (below 10%) in major fatty acids; palmitic, linoleic and linolenic acid in both of the seasons.…”

Section: Results and Discussion 1 Fatty Acid Compositionmentioning

confidence: 99%

“…As the saturated fatty acids increase the risks of cardiovascular diseases, cancer and autoimmune disorders (Iso et al, 2002), high ratio of such fatty acids in foods are not suitable for human health. In contrast, a diet rich in unsaturated fatty acids are more nutritional (Aronson et al, 2001) because a diet rich in mono unsaturated fatty acids such as oleic acid, may decrease blood cholesterol levels (Hargrove et al, 2001), improve high-density lipoprotein (HDL) fluidity (Villa et al, 2002) and protects against ischemic and stroke and lacunar the reduction in many cardiovascular diseases, cancer, asthma as well as depression (Simopoulos, 2002). So the compositional ratio of these fatty acids in any food products is an important factor that determines the nutritional value of the food.…”

Section: Introductionmentioning

confidence: 99%

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Seasonal variation in fatty acid composition in various parts of broccoli cultivars

Bhandari¹,

Park²,

Chae³

et al. 2013

Korean Journal of Agricultural Science

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:To evaluate seasonal variation in fatty acid composition in broccoli, 12 commercial cultivars of broccoli were grown in spring and fall season at the field of NIHHS, and their floret, leaf and stem parts were used for the fatty acid composition analyses. Among 14 fatty acids detected in broccoli, linolenic, palmitic and linoleic acids were major fatty acids comprising more than 80% of total fatty acids in both the seasons and all the parts. Likewise, stearic and oleic acids were also present in considerable amount while remaining fatty acids; caproic, lauric, myristic, pentadecanoic, palmitoleic, heptadecanoic, arachidic, behenic and lignoceric acids showed their minor compositional ratio. Among the three parts, stem exhibited highest SFAs (49.681% in spring and 50.717% in fall season) compared to MUFA and PUFA, while highest compositional ratio of PUFAs were observed in leaves (62.588% in spring and 68.931% in fall season), which indicates leaves as a good source of health beneficial fatty acids. In contrast, floret part exhibited highest SFA (48.786%) and PUFA (57.518%) in spring and fall seasons, respectively. Major fatty acids; palmitic, linoleic and linolenic acid showed lowest cultivar dependent variation (below 10%) and leaf showed least variation in both the seasons compared to floret and stem. Our results suggest that all the fatty acids are significantly influenced by genotype of cultivars (C), plant parts (P) and growing seasons (S). Among the 14 fatty acids, myristic and palmitic acid showed highest positive or negative correlationship with oleic (r=0.912**) and linolenic acid (r=-0.933**), respectively. The most abundant fatty acid, linolenic acid, showed either negative or no correlation ship with other fatty acids while palmitic acid, a second major fatty acid, exhibited either positive or negative correlation ship.

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Section: Results and Discussion 1 Fatty Acid Compositionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Seasonal variation in fatty acid composition in various parts of broccoli cultivars

Bhandari¹,

Park²,

Chae³

et al. 2013

Korean Journal of Agricultural Science

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“…Because effects of the nutrient composition of the meal on parasympathetic and sympathetic nervous system activity had been reported (37,38), indices of autonomic nervous system activity were also measured in the present study. However, activities of autonomic nervous systems during whole sleep and every sleep cycle were similar between the two dietary conditions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Nutrient Composition of Dinner on Sleep Architecture and Energy Metabolism during Sleep

Yajima

Seya

Iwayama

et al. 2014

J Nutr Sci Vitaminol

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Summary Energy metabolism and substrate oxidation during sleep correlate with sleep stage, suggesting that energy metabolism affects sleep architecture or vice versa. The aim of the present study was to examine whether changes in energy metabolism during sleep, induced by a high-carbohydrate or high-fat meal for dinner, affect sleep architecture. Ten healthy males participated in this study, sleeping 3 nonconsecutive nights in a whole-room calorimeter. The first night was scheduled as an adaptation to the experimental environment. The other 2 nights were experimental calorimetry in a balanced cross-over design with intrasubject comparisons. In each session, subjects comsumed a high carbohydrate (HCD: PFC510 : 10 : 80) or high fat (HFD: PFC510 : 78 : 12) meal at 2000 h and slept with a polysomnographic recording in a metabolic chamber for indirect calorimetry (0000 h to 0800 h). Slow wave sleep was decreased during the first sleep cycle and not changed during the second or third sleep cycle under HCD conditions compared with those of HFD. Energy expenditure was not affected by dietary condition but substrate oxidation reflected differences in dietary composition of the dinner during the first and second sleep cycle. The present study suggested the possibility that substrate availability during sleep affects substrate oxidation during sleep, and affects sleep architecture during the first sleep cycle.

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“…Some authors have suggested that the beneficial impact on SCD could be mediated by enhancing the heart rate variability (HRV), which represents the sympathetic and parasympathetic activities of the autonomic nervous system (ANS). A positive association between n-3 PUFAs and HRV has been observed in patients with type 1 diabetes mellitus (DM) (7), in those with coronary heart disease (8,9) as well as in healthy subjects (10)(11)(12)(13). In contrast, no changes in HRV parameters were observed in some studies conducted among healthy subjects (14)(15)(16) and haemodialysis patients (17).…”

Section: Introductionmentioning

confidence: 99%

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

Valera¹,

Dewailly

Anassour-Laouan-Sidi³

et al. 2011

International Journal of Circumpolar Health

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Objectives. Inuit from Nunavik (northern Quebec) consume large amounts of fish and marine mammals, which are important sources of n-3 polyunsaturated fatty acids (n-3 PUFAs). These substances have a beneficial impact on heart rate (HR) and heart rate variability (HRV). However, it is unknown if this beneficial impact remains significant in populations with high mercury exposure. The study assessed the impact of n-3 PUFAs (Docosahexaenoic [DHA] and Eicosapentaenoic acid [EPA]) on resting HR and HRV among Nunavik Inuit adults considering mercury and other potential confounders. Study design. Cross-sectional study employing clinical measurements. Methods. Complete data were collected among 181 adults ≥40 years old (109 women and 72 men) living in the 14 coastal villages of Nunavik. Several indices of HRV were derived from a 2-hour Holter monitoring assessment. n-3 PUFAs levels were measured in membrane erythrocytes. Simple linear regression was used to analyse the relationship between n-3 PUFAs levels and resting HR and HRV parameters while multiple linear regressions were carried out to control for confounders. Results. In the overall analyses, EPA was associated with SDANN (β=0.07, p=0.04) and LF norm (β=-1.84, p=0.03) after adjusting for confounders. Among women, DHA was associated with resting HR (β=-1.40, p=0.03) while EPA was associated with SDNN (β=0.08, p=0.03), SDANN (β=0.09, p=0.02) and resting HR (β=-2.61, p=0.002). No significant association was observed in men. Conclusions. These results suggest a beneficial impact of n-3 PUFAs on resting HR and HRV among Nunavik Inuit women.

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Omega-3 fatty acid ethyl esters increase heart rate variability in patients with coronary disease

Cited by 74 publications

References 12 publications

Seasonal variation in fatty acid composition in various parts of broccoli cultivars

Seasonal variation in fatty acid composition in various parts of broccoli cultivars

Effects of Nutrient Composition of Dinner on Sleep Architecture and Energy Metabolism during Sleep

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

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