Omega-3 Fatty Acid Prevents Heart Rate Variability Reductions Associated with Particulate Matter

Romieu, Isabelle; Téllez‐Rojo, Martha María; Lazo, Mariana; Manzano-Patiño, Abigail; Cortez‐Lugo, Marlene; Julien, Pierre; Bélanger, Marie Claire; Hernández-Ávila, Mauricio; Holguín, Fernando

doi:10.1164/rccm.200503-372oc

Cited by 123 publications

(98 citation statements)

References 38 publications

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“…Shortterm randomised supplementation trials suggest that antioxidant vitamins and n-3 polyunsaturated fatty acids might protect against the acute effect of these pollutants, particularly in vulnerable subgroups [80,96,106]. However, the evidence is still limited because of the small sample size in most studies and the lack of comprehensive assessment of baseline nutritional status and oxidative stress response.…”

Section: Resultsmentioning

confidence: 99%

“…In a randomised trial conducted in nursing home residents, supplementation with 2 g?day -1 of fish oil (each 1 g capsule contained 83.2 % of omega-3 fatty acids) significantly decreased the effect of PM2.5 on time and frequency domain parameters of HRV [106] This is one of two studies providing evidence that oxidant stress is one of the mechanisms explaining the effect of particle air pollution on the cardiovascular system [107]. The other study reported that statins had a mitigating effect on the HRV effects of particulate air pollution in subjects genetically susceptible to oxidative stress (lacking the GSTM1 allele) [108].…”

Section: Cardiovascular Effectmentioning

confidence: 98%

“…As observed in the case of cigarette smoke, a significant source of oxidative stress, air pollutants would lower antioxidant defences, with deleterious health consequences [116,117]. Evidence of the potential beneficial effect of antioxidants can be found in studies of elderly subjects in which treatment with statins [108] and n-3 PUFA supplementation [106] had a beneficial effect on response to particulate exposure.…”

Section: Chronic Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Air pollution, oxidative stress and dietary supplementation: a review

Romieu

Castro-Giner²,

Künzli³

et al. 2007

Eur Respir J

225

157

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The aim of the present review was to provide an up-to-date overview of the biological and epidemiological evidence of the role of oxidative stress as a major underlying feature of the toxic effect of air pollutants, and the potential role of dietary supplementation in enhancing antioxidant defences.A bibliographic search was conducted through PubMed. The keywords used in the search were ''air pollutant'', ''oxidative stress'', ''inflammation'', ''antioxidant polyunsaturated fatty acids'' and ''genetics''. In addition, the authors also searched for biomarkers of oxidative stress and nutrients.The review presents the most recent data on: the biological and epidemiological evidence of the oxidative stress response to air pollutants; the role of dietary supplementation as a modulator of these effects; and factors of inter-individual variation in human response. The methodology for further epidemiological studies will be discussed in order to improve the current understanding on how nutritional factors may act.There is substantial evidence that air pollution exposure results in increased oxidative stress and that dietary supplementation may play a modulating role on the acute effect of air pollutants. Further epidemiological studies should address the impact of supplementation strategies in the prevention of air-pollution-related long-term effects in areas where people are destined to be exposed for the distant future.

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Section: Resultsmentioning

confidence: 99%

Section: Cardiovascular Effectmentioning

confidence: 98%

Section: Chronic Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Air pollution, oxidative stress and dietary supplementation: a review

Romieu

Castro-Giner²,

Künzli³

et al. 2007

Eur Respir J

225

157

View full text Add to dashboard Cite

show abstract

“…The effects of PM 2.5 on HRV were mitigated by the use of statin drugs, which have antioxidant and antiinflammatory properties. 308 In a study of elderly nursing home residents in Mexico City, Mexico, Romieu et al 309 demonstrated that dietary supplementation of omega-3 polyunsaturated fatty acid significantly reduced the PM 2.5 -related decline in HRV.…”

Section: Altered Cardiac Autonomic Functionmentioning

confidence: 99%

Health Effects of Fine Particulate Air Pollution: Lines that Connect

Pope

Dockery²

2006

Journal of the Air & Waste Management Association

5,670

3,159

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Efforts to understand and mitigate the health effects of particulate matter (PM) air pollution have a rich and interesting history. This review focuses on six substantial lines of research that have been pursued since 1997 that have helped elucidate our understanding about the effects of PM on human health. There has been substantial progress in the evaluation of PM health effects at different time-scales of exposure and in the exploration of the shape of the concentration-response function. There has also been emerging evidence of PM-related cardiovascular health effects and growing knowledge regarding interconnected general pathophysiological pathways that link PM exposure with cardiopulmonary morbidity and mortality. Despite important gaps in scientific knowledge and continued reasons for some skepticism, a comprehensive evaluation of the research findings provides persuasive evidence that exposure to fine particulate air pollution has adverse effects on cardiopulmonary health. Although much of this research has been motivated by environmental public health policy, these results have important scientific, medical, and public health implications that are broader than debates over legally mandated air quality standards.

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“…Some authors have suggested that the beneficial impact on SCD could be mediated by enhancing the heart rate variability (HRV), which represents the sympathetic and parasympathetic activities of the autonomic nervous system (ANS). A positive association between n-3 PUFAs and HRV has been observed in patients with type 1 diabetes mellitus (DM) (7), in those with coronary heart disease (8,9) as well as in healthy subjects (10)(11)(12)(13). In contrast, no changes in HRV parameters were observed in some studies conducted among healthy subjects (14)(15)(16) and haemodialysis patients (17).…”

Section: Introductionmentioning

confidence: 99%

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

Valera¹,

Dewailly

Anassour-Laouan-Sidi³

et al. 2011

International Journal of Circumpolar Health

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Objectives. Inuit from Nunavik (northern Quebec) consume large amounts of fish and marine mammals, which are important sources of n-3 polyunsaturated fatty acids (n-3 PUFAs). These substances have a beneficial impact on heart rate (HR) and heart rate variability (HRV). However, it is unknown if this beneficial impact remains significant in populations with high mercury exposure. The study assessed the impact of n-3 PUFAs (Docosahexaenoic [DHA] and Eicosapentaenoic acid [EPA]) on resting HR and HRV among Nunavik Inuit adults considering mercury and other potential confounders. Study design. Cross-sectional study employing clinical measurements. Methods. Complete data were collected among 181 adults ≥40 years old (109 women and 72 men) living in the 14 coastal villages of Nunavik. Several indices of HRV were derived from a 2-hour Holter monitoring assessment. n-3 PUFAs levels were measured in membrane erythrocytes. Simple linear regression was used to analyse the relationship between n-3 PUFAs levels and resting HR and HRV parameters while multiple linear regressions were carried out to control for confounders. Results. In the overall analyses, EPA was associated with SDANN (β=0.07, p=0.04) and LF norm (β=-1.84, p=0.03) after adjusting for confounders. Among women, DHA was associated with resting HR (β=-1.40, p=0.03) while EPA was associated with SDNN (β=0.08, p=0.03), SDANN (β=0.09, p=0.02) and resting HR (β=-2.61, p=0.002). No significant association was observed in men. Conclusions. These results suggest a beneficial impact of n-3 PUFAs on resting HR and HRV among Nunavik Inuit women.

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Omega-3 Fatty Acid Prevents Heart Rate Variability Reductions Associated with Particulate Matter

Abstract: Supplementation with 2 g/d of fish oil prevented HRV decline related to PM2.5 exposure in the study population.

Cited by 123 publications

References 38 publications

Air pollution, oxidative stress and dietary supplementation: a review

Air pollution, oxidative stress and dietary supplementation: a review

Health Effects of Fine Particulate Air Pollution: Lines that Connect

Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults

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