Omega-3 fatty acids and neurological injury

Michael‐Titus, Adina T.

doi:10.1016/j.plefa.2007.10.021

Cited by 54 publications

(31 citation statements)

References 38 publications

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“…Many studies show that omega-3 PUFAs have significant therapeutic potential in SCI and our data suggest a similar result (3,9,11,15). Most preparations used at present contain a significant amount of soybean oil and therefore have a considerable omega-6 component.…”

Section: Discussionsupporting

confidence: 82%

“…Robson et al (18) showed that omega-3 PUFA such as DHA, can be harnessed to promote neurite recovery after injury in vivo. Omega-3 PUFA has a marked neurite-promoting potential in neurons from adult and aged animals, seen both at the adult and aged stage (15). VEGF treatment resulted in earlier improvement in locomotor ability during the chronic phase of SCI (15).…”

Section: Tural Emon S Et Al: Parenteral Nutritional Supportmentioning

confidence: 99%

“…(15). Traumatic injuries of the spinal cord lead to death of neuronal and glial cells and to degeneration of the ascending and descending tracts.…”

Section: Introductionmentioning

confidence: 99%

“…Mostly young patients, between 16 and 30 years old have SCI (15). The life expectancy for these patients is long and the patient's quality of life and cost of their neurological disorders depend on the prevention or treatment of secondary injury that occurs after primary SCI.…”

Section: Introductionmentioning

confidence: 99%

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Effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury

Emon¹,

İrban²,

Bozkurt³

et al. 2010

Turkish Neurosurgery

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AIm: Aim of this study is to assess effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury. mAterIAl and methOds: For 5 days after SCI rats were received saline in group C and Omegaven in group O. Locomotor strengths (BBB scale)of animals were rated at Day 0,7,14,21,28, and 35. At Day 35 spinal cord sampling was evaluated immunohistochemically.results: BBB scores were 0 in early period after SCI was inflicted in both groups. BBB scores were progressively increased after Day 7 in both groups (p<.005). BBB scores were significantly higher in group O when compared with control group after Day7 in all times (p<.005). Neuronal injury (p<.002) and edema was much more in control group when compared with in group O (p<.005). Scores for white mater cavitation, demyelinization and vessel in growth were similar in both groups. VEGF expression in control group was higher (p=.019).COnClusIOn: At the early period of SCI fish-oil emulsion treatment in rats, its anti-inflammatory effects leaded to decrease in edema and had positive effect at the prevention of neuronal injury. We believe that nutritional support with fish-oil emulsion in patients with SCI will result in patient's better clinical outcome and increase in quality of the patient's life.KeywOrds: Omega-3 fatty acids, Omega-6 fatty acids, Neuron recovery, Nutrition, Spinal cord injury ÖZ AmAÇ: Travmatik omurilik yaralanması olan sıçanlarda omegaven ile beslenme desteğinin iyileşme üzerine etkilerinin araştırılmasıdır. yÖntem ve GereÇ: Omurilik hasarını takiben 5 gün boyunca sıçanlara IP 1mL/kg omegaven veya 0.9NaCl verildi. Lokomotor kuvvet (BBB skoru)0,7,14,21,28 ve 35.günlerde kaydedildi. Otuzbeşinci günde omurilikte histopatolojik inceleme yapıldı.BulGulAr: Kontrol grubunda BBB skorları düşük (p<.005), nöronal hasarlanma (p<.002) ve ödem (p<.005) yüksek bulundu. Beyaz maddede kavitasyon, demiyelinizasyon ve damarlanma skorlarında fark saptanmadı. VEGF kontrol grubunda yüksek bulundu(p=.019).sOnuÇ: Erken dönemde omurilik hasarında balık yağı emulsiyonu ile beslenme desteğinin antiinflamatuar etki ile ödemi azalttığı ve nöronal hasar üzerine koruyucu etkisi olduğu görüldü. Omurilik yaralanması olan hastalarda balık yağı emulsiyonu ile beslenme desteği daha iyi klinik sonuçlar ve daha yüksek yaşam kalitesi sağlayabilir.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Tural Emon S Et Al: Parenteral Nutritional Supportmentioning

confidence: 99%

“…(15). Traumatic injuries of the spinal cord lead to death of neuronal and glial cells and to degeneration of the ascending and descending tracts.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury

Emon¹,

İrban²,

Bozkurt³

et al. 2010

Turkish Neurosurgery

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show abstract

“…71 In rodent models, DHA supplementation post-moderate TBI was shown to decrease number of axon apoptosis and to increase hippocampal neurons as well as decrease pro-inflammatory cytokines and markers of oxidative stress. [71][72][73][74][75][76] Rodent models have also been fairly consistent in demonstrating a beneficial effect of DHA supplementation through multiple signaling pathways in brain injury, spinal cord injury and cardiac ischemia-reperfusion. 65 Specifically in models of head injury, prophylactic supplementation with DHA attenuates white matter damage, as evidenced by fewer beta amyloid precursor-positive axons, enhanced preservation of myelin, and protection of neurofilament morphology.…”

Section: Dhamentioning

confidence: 90%

Nutrition as Medicine to Improve Outcomes in Adolescents Sustaining a Sports-related Concussion

Casazza¹,

Swanson²

2017

Exploratory Research and Hypothesis in Medicine

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Recognition and diagnosis of sports-related concussion (SRC) among adolescents has significantly increased. In, fact, among high school adolescents, SRC incidence has more than doubled from 2007 to 2014, with recent estimates at approximately 2 per 100 athletes. SRC-related research has also increased; recognition of symptoms that may prolong recovery have been examined, potential biomarkers have been scrutinized, return-to-learn and return-to-play protocols have been developed and honed. However, to date, clinicians and researchers have struggled to find effective interventions to mitigate the significant symptoms after SRC and shorten recovery times. Despite the understood role of the brain as the primary regulator of metabolism, and the well-established metabolic impairments evoked after a concussion, nutrition is often ignored as a core complement to the recovery and rehabilitation process. In this article, we will identify deficiencies and/or inadequacies in nutrients post-concussion and provide support for potential exacerbation of injury and delayed recovery due to inadequate intake of nutrients prior to sustaining an SRC. Additionally, we will discuss the effect of derangement of the metabolic cascade post-concussion, and identify key nutrients, that if supplemented immediately post-injury, could increase neuroprotection, and improve recovery outcomes. Animal and cell culture studies have provided substantial evidence for not only the interrelationship of nutrient adequacy and the adaptation in the metabolic cascade post-concussion on neuroprotection, but also key nutrients that if supplemented immediately post-injury could enhance standard of care with minimal risk.

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Spinal Cord Injury

Gensel

2014

Neuroinflammation and CNS Disorders

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Omega-3 fatty acids and neurological injury

Cited by 54 publications

References 38 publications

Effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury

Effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury

Nutrition as Medicine to Improve Outcomes in Adolescents Sustaining a Sports-related Concussion

Spinal Cord Injury

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