Omega-3 fatty acids as an adjunct for periodontal therapy—a review

Chee, Brian; Park, B.; Fitzsimmons, Tracy; Coates, Alison M.; Bartold, P. Mark

doi:10.1007/s00784-016-1750-2

Cited by 38 publications

(41 citation statements)

References 178 publications

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“…This result may be due to the efforts of the participants to avoid animal products and instead focus on plant sources like flaxseeds or flaxseed oil. Beside the low conversion rate of linoleic acid to EPA and DHA, most clinical successful studies on periodontal inflammation were performed with supplemented EPA and DHA (Chee, Park, Fitzsimmons, Coates, & Bartold, ). Thus, the AID protocol may benefit from an emphasized recommendation for animal sources (e.g., a portion of fatty sea fish like salmon, mackerel, or herring) or supplementation of omega‐3 fatty acids (Brenna, Salem, Sinclair, & Cunnane, ).…”

Section: Discussionmentioning

confidence: 99%

The influence of an anti‐inflammatory diet on gingivitis. A randomized controlled trial

Woelber

Gärtner

Breuninger

et al. 2019

J Clinic Periodontology

100

175

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Aim Aim of this study was to investigate the influence of an anti‐inflammatory diet on different parameters in patients with gingivitis. Materials and Methods Thirty patients were randomly allocated to an experimental and a control group stratified by their plaque values. The experimental group had to change to a diet low in processed carbohydrates and animal proteins, and rich in omega‐3 fatty acids, vitamin C, vitamin D, antioxidants, plant nitrates and fibres for 4 weeks. The control group did not change their diet. Both groups suspended interdental cleaning. Periodontal parameters were assessed by a blinded dentist. Serological and subgingival plaque samples were taken at baseline and end. Results While there were no differences regarding the plaque values, the experimental group showed a significant reduction in gingival bleeding (GI Baseline: 1.04 ± 0.21, GI End: 0.61 ± 0.29, p < 0.05), a significant increase in Vitamin D values and a significant weight loss. There were no inter‐group differences regarding the inflammatory serological parameters, the serological omega fatty acids, nor the subgingival microbiome composition. Conclusion The evaluated diet could significantly reduce gingivitis in a clinically relevant range, while serological inflammatory parameters and the subgingival microbiome seem to be unaffected in this study duration. (German Clinical Trials Register; DRKS00009888).

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Section: Discussionmentioning

confidence: 99%

The influence of an anti‐inflammatory diet on gingivitis. A randomized controlled trial

Woelber

Gärtner

Breuninger

et al. 2019

J Clinic Periodontology

100

175

View full text Add to dashboard Cite

show abstract

“…Clinical studies have indicated that dietary supplementation with omega‐3 polyunsaturated fatty acids (precursors of resolvins and protectins) may provide a benefit to the treatment of the disease, especially when combined with aspirin . In this regard, aspirin acetylates and changes the enzymatic function of cyclooxygenase‐2, triggering the production of E‐resolvins from eicosapentaenoic acid and D‐resolvins and protectins from docosahexaenoic acid .…”

Section: Specialized Pro‐resolution Mediatorsmentioning

confidence: 99%

Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy

Hajishengallis

Chavakis

Lambris

2020

Periodontology 2000

266

165

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Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a consequence of dysbiosis but, via mediating tissue dysfunction and damage, fuels further growth of selectively dysbiotic communities of bacteria (inflammophiles), thereby generating a self‐sustained feed‐forward loop that perpetuates the disease. These considerations provide a strong rationale for developing adjunctive host‐modulation therapies for the treatment of periodontitis. Such host‐modulation approaches aim to inhibit harmful inflammation and promote its resolution or to interfere directly with downstream effectors of connective tissue and bone destruction. This paper reviews diverse strategies targeted to modulate the host periodontal response and discusses their mechanisms of action, perceived safety, and potential for clinical application.

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“…Erste klinische Studien konnten bereits den positiven Einfluss einer adjunktiven Einnahme von Omega-3-Fettsäuren zusätzlich zur Parodontitistherapie bezüglich Sondierungstiefenreduktion und Entzündungsreaktion zeigen [29].…”

Section: Merkeunclassified

“…Bei einer vegetarischen oder veganen Ernährungsweise sollte auf eine ausreichende Zufuhr von Vitamin B 12 und Omega-3-Fettsäuren geachtet werden, da ein Mangel dieser Nährstoffe neben allgemeingesundheitlichen auch mit negativen parodontalen Gesundheitskonsequenzen einhergehen kann [29,35].…”

Section: Einfluss Der Proteineunclassified

Ernährung und parodontale Gesundheit

Wölber¹,

Gärtner²

2019

ZWR

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Omega-3 fatty acids as an adjunct for periodontal therapy—a review

Abstract: The host modulatory properties of omega-3 fatty acids warrant further assessment of their use as an adjunct in the management of periodontitis.

Cited by 38 publications

References 178 publications

The influence of an anti‐inflammatory diet on gingivitis. A randomized controlled trial

The influence of an anti‐inflammatory diet on gingivitis. A randomized controlled trial

Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy

Ernährung und parodontale Gesundheit

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