Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial

Su, Kuan Pin; Lai, Hsueh Chou; Yang, Hui; Su, Wen Pang; Peng, Cheng Yuan; Chang, Jong Sun; Chang, Hung Chi; Pariante, Carmine M.

doi:10.1016/j.biopsych.2014.01.008

Cited by 181 publications

(135 citation statements)

References 81 publications

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“…These strategies not only include the use of omega-3 polyunsaturated fatty acids (n-3 PUFA) and antioxidants (for reviews, see Bazinet and Laye, 2014;Gomez-Pinilla and Nguyen, 2012) but also compounds that beneficially alter the microbiota (eg, prebiotics or probiotics) (Cryan and Dinan, 2012). Relevant to the role of inflammation in promoting effects of nutritional interventions on depressive symptoms, the n-3 PUFA eicosapentaenoic acid (EPA) was recently found to be effective in the prevention of IFN-α-induced depression in hepatitis C-infected patients (Su et al, 2014). In addition, a recent report indicates that patients with major depression and high level of systemic inflammation, which highly correlates with increased BMI, are more likely to respond to EPA treatment than depressed subjects with low inflammation (Rapaport et al, 2016).…”

Section: Non-pharmacological Interventionsmentioning

confidence: 99%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

141

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Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.

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Section: Non-pharmacological Interventionsmentioning

confidence: 99%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

141

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“…Epidemiological studies [5,6], case-control studies [7][8][9][10][11][12] , and clinical trials [13][14][15][16][17][18] all suggest that n-3 PUFAs might play an important role in major depressive disorder (MDD). Moreover, genotypes of the key enzymes for phospholipids metabolism, such as Phospholipase A2 (PLA2) and cyclo-oxygenase-2 (COX-2), have been associated with major depressive disorder [19,20] and Interferon (IFN)-α induced depression [21].…”

Section: Introductionmentioning

confidence: 99%

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Chang

Guu

Chen

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Somatic symptoms are commonly seen in patients with major depressive disorder (MDD) and might be associated with inflammatory activation. Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. This study investigated the effects of BanI polymorphism of cPLA2 gene and COX-2 rs4648308 genotypes on somatic symptoms and inflammatory marker in patients with MDD.Eighty-two patients with MDD were assessed for their psychopathology including 2 psychiatric and somatic symptoms, BanI polymorphism of cPLA2 and COX-2 rs4648308 genotypes and CRP levels. The results revealed that MDD patients with the cPLA2 BanI GG genotypes had higher somatic symptoms and higher levels of C-reactive protein (CRP), while no differences were found among the COX-2 rs4648308 genotypes. Inflammatory process, such as arachidonic acid cascade pathway, might help explain the effect of cPLA2 BanI polymorphism on the somatic symptoms, and may be a potential target for future investigation on treatment for MDD with somatic symptoms. However, the interpretation of the findings in this study is limited since we analyzed the data from a subset data from a larger study.

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“…10 To test the hypothesis that lower omega-3 PUFA levels reflect less "endogenous anti-inflammatory capability" in those who later develop depression, my colleagues and I conducted a 2-week double-blind RCT to test the effects of omega-3 PUFA supplementation in the prevention of IFN-α-induced depression. 11 We found that incident rates of IFN-α-induced depression were significantly lower in EPA-treated patients, but not DHA-or placebo-treated patients. This study further confirms the notion that omega-3 PUFAs may be effective antidepressants in the context of depression associated with inflammation.…”

Section: Personalized Medicine With Omega-3 Fatty Acids For Depressiomentioning

confidence: 62%

Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial

Cited by 181 publications

References 81 publications

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Role of Adiposity-Driven Inflammation in Depressive Morbidity

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Personalized Medicine With Omega-3 Fatty Acids for Depression in Children and Pregnant Women and Depression Associated With Inflammation

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