Omega-3 Polyunsaturated Essential Fatty Acid Status as a Predictor of Future Suicide Risk

Sublette, M. Elizabeth; Hibbeln, Joseph R.; Galfalvy, M. Hanga; Oquendo, María A.; Mann, J. John

doi:10.1176/ajp.2006.163.6.1100

Cited by 179 publications

(99 citation statements)

References 15 publications

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“…Genetic and developmental factors must be considered. Another option is based on the observation that omega 3 polyunstaturated fatty acids (PUFAs) are thought to be deficient relative to omega 6 PUFAs in suicide attempters and suicides [60], and that relative deficiency may predict the risk for suicidal behaviour [61]. Not all studies find these relationships [62], but the findings raise the question of what mechanisms relate PUFAs to suicidal behaviour?…”

Section: The Neural Circuitry Of the Diathesis For Suicidal Behaviourmentioning

confidence: 99%

The serotonergic system in mood disorders and suicidal behaviour

Mann

2013

Phil. Trans. R. Soc. B

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191

117

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A stress-diathesis explanatory model of suicidal behaviour has proved to be of heuristic value, and both clinical and neurobiological components can be integrated into such a model. A trait deficiency in serotonin input to the anterior cingulate and ventromedial prefrontal cortex is found in association with suicide, and more recently non-fatal suicidal behaviour, and is linked to decision-making and suicide intent by imaging and related studies in vivo . The same neural circuitry and serotonin deficiency may contribute to impulsive aggressive traits that are part of the diathesis for suicidal behaviour and are associated with early onset mood disorders and greater risk for suicidal behaviour. Other brain areas manifest deficient serotonin input, that is, a trait related to recurrent major depressive disorder and bipolar disorder. Thus the serotonin system is involved in both the diathesis for suicidal behaviour in terms of decision-making, and to a major stressor, namely episodes of major depression.

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Section: The Neural Circuitry Of the Diathesis For Suicidal Behaviourmentioning

confidence: 99%

The serotonergic system in mood disorders and suicidal behaviour

Mann

2013

Phil. Trans. R. Soc. B

Self Cite

191

117

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“…This association has been found in a few studies having a prospective design, which suggests the existence of a causal link between a low intake or status of n-3 PUFA and an increased risk of subsequent depression [25][26][27] (Astorg, unpublished).…”

Section: Apparent Fish and Seafood Consumption And Prevalence Of Bimentioning

confidence: 87%

“…The decrease of risk is more pronounced in men than in women, and is especially marked for very recurrent episodes (three or more). In a small prospective study in USA, blood has been taken up from 31 depressed inpatients, and their suicide attempts have been recorded during two years after discharge [26]. A lower plasma DHA level at baseline was predictive of subsequent suicide attempt: OR = 3.45, p = 0.002 (below vs. above the median DHA value) (figure 5).…”

Section: Blood and Tissue N-3 Pufa And Depression : Observations In CLImentioning

confidence: 99%

Omega-3 polyunsaturated fatty acids and mood disorders

Astorg¹

2007

OCL

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“…14 Furthermore, Parker et al 3 reviewed several studies that show a correlation between depression and cardiovascular ailments. Interventions aimed at increasing blood levels of omega-3 fatty acids may help to prevent depression and adverse cardiovascular events.…”

Section: Previous Researchmentioning

confidence: 99%

Food as medicine in psychiatric care: Which profession should be responsible for imparting knowledge and use of omega-3 fatty acids in psychiatry

Johannessen

Skagestad

Bergkaasa

2011

Complementary Therapies in Clinical Practice

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a b s t r a c t Keywords: Omega3 Fatty acids Psychiatric care CAMThe effect of omega-3 fatty acids on depression is well documented. The purpose of this study was to determine if and how food is used as medicine in psychiatric care, especially how omega-3 fatty acids are used as a supplement in the treatment of depression. This is a pilot study with a qualitative design using questionnaires and interviews among nursing students, tutor nurses and psychiatrists. Three main categories emerged: 1. Nutrition is considered important but few evaluations are made. 2. There was a lack of knowledge of the effects of Omega 3. 3. There was an unclear divisions of responsibility among health personell. A change in knowledge paradigms and clarification of responsibility is called for if foodas-medicine is to take its true place in psychiatric care. It is also necessary to include CAM and holistic perspectives. Further research is needed to determine why health education and health workers do not focus on nutrition therapy in psychiatric care. Further research is also needed to reveal both the patients, the GPs and the CAM practitionaires knowledge and attitude to the use of dietary supplements.

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Omega-3 Polyunsaturated Essential Fatty Acid Status as a Predictor of Future Suicide Risk

Abstract: A low docosahexaenoic acid percentage and low omega-3 proportions of lipid profile predicted risk of suicidal behavior among depressed patients over the 2-year period. If confirmed, this finding would have implications for the neurobiology of suicide and reduction of suicide risk.

Cited by 179 publications

References 15 publications

The serotonergic system in mood disorders and suicidal behaviour

The serotonergic system in mood disorders and suicidal behaviour

Omega-3 polyunsaturated fatty acids and mood disorders

Food as medicine in psychiatric care: Which profession should be responsible for imparting knowledge and use of omega-3 fatty acids in psychiatry

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