Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients

Edwards, Rhian; Peet, Malcolm; Shay, Janet; Horrobin, David F.

doi:10.1016/s0165-0327(97)00166-3

Cited by 413 publications

(267 citation statements)

References 19 publications

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“…Previous studies reported that levels of EPA and DHA in serum or in the red blood cell membrane were lower in subjects with major depression than in healthy controls (Edwards et al, 1998;Peet et al, 1998;Maes et al, 1999). In the present study, there were no differences in the levels of DHA and EPA in serum phospholipids between subjects with major depression and subjects without depression.…”

Section: Serum Fatty Acid and Depression In Cancer Patients M Kobayakcontrasting

confidence: 65%

“…However, subjects with depression had significantly lower intake of ALA, which was a major dietary omega-3 FA (Suzuki et al, 2004). As ingested ALA can be converted into EPA and DHA in vivo, the result of our previous study (Suzuki et al, 2004) did not seem to be inconsistent with the studies indicating lower levels of EPA and DHA in phospholipids in depression (Edwards et al, 1998;Peet et al, 1998;Maes et al, 1999). Then, in the present study, we hypothesised that lower levels of EPA and DHA in serum phospholipids were associated with major depression and minor depression in lung cancer patients.…”

Section: Serum Fatty Acid and Depression In Cancer Patients M Kobayakmentioning

confidence: 59%

“…Docosahexaenoic acid (DHA), one of the omega-3 fatty acids (FAs), is a major component of membrane FAs in brain neural cells and lack of DHA has been shown to alter neural transmission in animal studies (Bruinsma and Taren, 2000;Innis, 2000;Ng and Innis, 2003). Previous studies have shown associations between DHA or its precursor, eicosapentaenoic acid (EPA, omega-3 FA), and major depression in subjects without cancer (Edwards et al, 1998;Hibbeln, 1998;Peet et al, 1998;Maes et al, 1999). Other studies have shown their possible therapeutic potential with few adverse effects in clinical trials (Nemets et al, 2002;Peet and Horrobin, 2002;Su et al, 2003).…”

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Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

et al. 2005

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Previous studies suggested that omega-3 fatty acids (FAs) have therapeutic effects against depression, but there is no evidence in the oncological setting. Our preliminary study reported the association between lower omega-3 FA intake and occurrence of depression in lung cancer patients. To explore the association further, the present study examined whether depression was associated with lower levels of omega-3 FAs in serum phospholipids. A total of 717 subjects in the Lung Cancer Database Project were divided into three groups by two cutoff points of the Hospital Anxiety and Depression Scale depression subscale (HADS-D). In all, 81 subjects of the nondepression and minor depression groups (HADS-Do5 and 5pHADS-Dp10, respectively) were selected to match with 81 subjects of the major depression group (HADS-D410) for age, gender, clinical stage, and performance status. Fatty acids were assayed by gas chromatography and compared among the three matched groups. There were no differences between the major depression group and nondepression group in any FAs. The minor depression group had higher mean levels of docosahexaenoic acid (mean7s. Major and minor depressions are one of the most common psychiatric problems in clinical oncological settings (Derogatis et al, 1983;Razavi and Stiefel, 1994;McDaniel et al, 1995). Docosahexaenoic acid (DHA), one of the omega-3 fatty acids (FAs), is a major component of membrane FAs in brain neural cells and lack of DHA has been shown to alter neural transmission in animal studies (Bruinsma and Taren, 2000;Innis, 2000;Ng and Innis, 2003). Previous studies have shown associations between DHA or its precursor, eicosapentaenoic acid (EPA, omega-3 FA), and major depression in subjects without cancer (Edwards et al, 1998;Hibbeln, 1998;Peet et al, 1998;Maes et al, 1999). Other studies have shown their possible therapeutic potential with few adverse effects in clinical trials (Nemets et al, 2002;Peet and Horrobin, 2002;Su et al, 2003). In the oncological setting, the use of antidepressants has been limited due to their adverse effects (Akizuki et al, 2002;Fisch, 2004). In our previous pilot study to obtain information for planning interventional research, depression in cancer patients was not associated with either EPA or DHA intakes, but was associated with lower intake of alpha-linolenic acid (ALA: major omega-3 FAs in diet, precursor of EPA and DHA) (Suzuki et al, 2004). To elucidate any such association in detail, the present study was designed to examine our hypothesis that lower levels of omega-3 FAs (EPA, DHA) in serum phospholipids are associated with major and minor depression in lung cancer patients. MATERIALS AND METHODS Study design and subjectsThe present study was a three matched group case -control study, based in part on the Lung Cancer Database Project, which was a prospective cohort study for investigation of the pathogenesis of and development of new therapy for lung cancer at the National Cancer Center Hospital East and the National Cancer Center Research Institute East, ...

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Section: Serum Fatty Acid and Depression In Cancer Patients M Kobayakcontrasting

confidence: 65%

Section: Serum Fatty Acid and Depression In Cancer Patients M Kobayakmentioning

confidence: 59%

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confidence: 99%

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Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

et al. 2005

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“…Epidemiological findings linking depression and low levels of fish intake have been reported (Hibbeln, 1998;Tanskanen et al, 2001), and biochemical research has also shown that the concentrations of each o-3 FA are significantly lower in the serum or red blood cell membranes of depressed patients than in control subjects (Edwards et al, 1998;Peet et al, 1998;Maes et al, 1999). Ethyl-EPA augmentation therapy has been reported to improve depressive symptoms in patients with major depression in randomised placebo-controlled double-blind clinical trials (Nemets et al, 2002;Peet and Horrobin, 2002) and in one clinical report (Puri et al, 2002).…”

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Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

et al. 2004

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The aim of the present study was to examine the association between daily omega-3 fatty acid intake and depression in Japanese cancer patients. Omega-3 fatty acid intake in 771 patients with newly diagnosed primary lung cancer was evaluated using a foodfrequency questionnaire, and the prevalence of depression was examined using the cutoff values for the depression subscale included in the Hospital Anxiety and Depression Scale. After adjustment for potential confounding factors, the odds ratio (OR) for depression among patients in the highest quartile of the total eicosapentaenoic acid-(C20:5n-3) and docosapentaenoic acid (C22:6n-3)-intake group compared with patients in the lowest quartile was not significantly different. On the other hand, the OR among the highest quartile of a-linolenic acid (C18:3n-3) intake (adjusted OR ¼ 0.50, 95% CI: 0.31 -0.71, P for trend ¼ 0.004) and the highest quartile of total omega-3 fatty acid intake (adjusted OR ¼ 0.55, 95% CI: 0.35 -0.88, P for trend ¼ 0.022) were significantly different. These results suggest that total eicosapentaenoic acid and docosapentaenoic acid intake might not be associated with depression in Japanese patients with newly diagnosed lung cancer, but that a-linolenic acid intake and total omega-3 fatty acid intake might be.

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“…The increase in carbohydrate consumption primarily came from an increase in sucrose (simple carbohydrate) intake 11 . With regard to micronutrients, two studies found an association between depression and low intake or serum levels of n 2 3 fatty acids 12,13 and several studies have found an association between depression and folate and vitamin B 12 deficiency [14][15][16][17] .…”

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Declines in dietary macronutrient intake in persons with HIV infection who develop depression

Isaac

Jacobson

Wanke

et al. 2008

Public Health Nutr.

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Background: The effect of depression on dietary intake has not, to our knowledge, been examined in persons with HIV infection. Methods: We conducted a longitudinal analysis of participants in the Nutrition for Healthy Living Study (NFHL). We measured changes in dietary macronutrient intake in participants who developed depression and, using multiple regression analysis, compared the changes with a control group of patients who did not become depressed. Results: Ninety patients developed depression during the observation period, and we compared these with 152 non-depressed controls. The two groups had similar age and body mass index (BMI) at baseline, but those who developed depression were more likely to be female, less educated and had lower incomes. After adjustment, compared with non-depressed participants, those who developed depression had significantly greater decreases in the following daily intakes: total energy (2341 kcal, P 5 0.006), protein (212.3 g, P 5 0.02), total fat (218.5 g, P 5 0.008), carbohydrate (236.8 g, P 5 0.02), total fibre (24.3 g, P 5 0.001) and saturated fat (26.7 g, P 5 0.01). There were no significant differences in the daily intakes of simple sugars and long-chain n23 fatty acids, or BMI. Conclusion: Depression is associated with decreases in total daily energy intake and in six of the eight dietary components we measured. Clinicians should be aware that depression-associated nutritional deficiencies may complicate the care of persons with HIV.

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Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients

Cited by 413 publications

References 19 publications

Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

Declines in dietary macronutrient intake in persons with HIV infection who develop depression

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