Omental acinar cell carcinoma of pancreatic origin in a child: a clinicopathological rarity

Sharma, Swati; Agarwal, Shipra; Nagendla, Murali Krishna; Gupta, Devendra K.

doi:10.1007/s00383-015-3850-5

Cited by 11 publications

(8 citation statements)

References 13 publications

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“…Heterotopic tissue may cause symptoms related to mechanical complications, such as gastric outlet obstruction [9] or intussusception [21, 22]; in other circumstances, heterotopic pancreatic tissue may cause bleeding from the surrounding intestinal mucosa [23]. Occasionally, metaplastic changes may occur in heterotopic tissue, leading to the development of malignancy in adulthood [5, 24, 25]; even though exceedingly rare, malignancies arising from heterotopic pancreas have been described also in children [26–28]. In our series, 7 out of 14 patients (50%) had symptoms related to the presence of heterotopic pancreas; presenting complaint were recurrent vomiting, dyspepsia, intussusception, bleeding and recurrent abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

Heterotopic pancreas in the gastrointestinal tract in children: a single-center experience and a review of the literature

et al. 2019

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BackgroundHeterotopic pancreas, that is the abnormal localization of a well-differentiated pancreatic tissue, is a rare occurrence in pediatric patients. Most lesions are found incidentally; in some circumstances, the presence of heterotopic pancreas may cause gastrointestinal symptoms, such as obstructive symptoms or bleeding.Patients and methodsThe clinical notes of patients with histological diagnosis of heterotopic pancreas treated at Meyer Children’s Hospital between 2009 and 2017 have been retrospectively examined.Four variables have been examined: clinical presentation, age at diagnosis, timing of surgery and localization of the heterotopic pancreas. Patients have been classified accordingly.ResultsFourteen patients were diagnosed with heterotopic pancreas at a single institution. In half cases, heterotopic pancreas caused symptoms that warranted surgical exploration. Symptomatic patients were significantly older than patients in whom heterotopic pancreas was an incidental finding (mean age 9 years and 5 months vs 2 years and 9 months; p = 0.02). Heterotopic pancreas was more frequently found in patients who underwent urgent surgical procedure than in patients who underwent elective surgery (2.61% vs 0.22%; p < 0.0001). In all cases, foci of heterotopic pancreas were resected.ConclusionHeterotopic pancreas is usually discovered in the submucosa of the stomach, duodenum and small bowel. Heterotopic tissue may cause symptoms related to mechanical complications, bleeding from the surrounding intestinal mucosa or, occasionally, to the development of malignancy.Heterotopic tissue is a rare but clinically relevant cause of gastrointestinal symptoms. The presence of heterotopic tissue should be considered in children with gastrointestinal symptoms of unclear origin and surgical resection is advisable.

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Section: Discussionmentioning

confidence: 99%

Heterotopic pancreas in the gastrointestinal tract in children: a single-center experience and a review of the literature

et al. 2019

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“…When symptomatic It can present as intestinal bleeding, obstruction, intussusception, or malignant transformation. [7][8][9] The etiology is unclear, several theories have been proposed. One mentions that the embryonic cells could be transported to adjacent structures during the bowel axial rotation, which would certainly explain the described locations.…”

Section: Discussionmentioning

confidence: 99%

Jejunal ectopic pancreas in a neonate

Acosta-Farina¹,

Oliveros-Rivero

Cabrera-Viteri³

et al. 2022

J Neonatal Surg

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An 18-hour-old male newborn transferred from another medical center, born by emergency c-section performed due to previous c-section and amniotic fluid leakage (15 days). The baby was born at 40 weeks gestation with a birth weight of 2590 g, length of 49 cm, and APGAR scores of 7-9 at 1-5 min, respectively. Oxygen was administered through the nasal cannula due to difficulty in breathing. O2 saturation improved from 80 % to 92%. Dextrose bolus was used to correct hypoglycemia (32 mg/dl). The patient was hospitalized in the NICU.

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“…In addition, Dall'igna et al [6] reviewed 21 patients aged 18 years or younger with pancreatic tumors reported in Italy between 2000 and 2009, including 2 cases of ACC. Table 2 summarizes the 26 reported pediatric cases, including the patients from the above reports and our case [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Although the details are often unclear, the following characteristics of pediatric ACC can be suggested: (1) the tumors tend to be very large at diagnosis, (2) distant metastasis is rare and in most cases lesions are (9).…”

Section: Discussionmentioning

confidence: 99%

Acinar cell carcinoma of the pancreas in childhood

et al. 2016

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A 12-year-old Japanese girl with pancreatic acinar cell carcinoma is presented. She was referred to our hospital with upper abdominal pain on exercise. Computed tomography scan showed a 17 9 17 9 12 cm heterogeneous mass in the right abdominal cavity centering around the pancreatic head to the anterior pararenal space. We performed pylorus-preserving pancreatoduodenectomy, because the tumor invaded the pancreatic head. Macroscopically, the tumor was a 19 9 18 cm, encapsulated mass derived from the pancreatic head without invasion to the surrounding organs, and consisted of solid and cystic portions. Histological examination showed tumor cells proliferating in an acinar pattern and invading the duodenal muscle layer. Immunohistochemically, tumor cells were positive for a1 trypsin and a1 chymotrypsin. From these histological findings, we diagnosed the lesion as an acinar cell carcinoma of the pancreas. We report this case of childhood acinar cell carcinoma, which is extremely rare, with a review of the literature.

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Omental acinar cell carcinoma of pancreatic origin in a child: a clinicopathological rarity

Cited by 11 publications

References 13 publications

Heterotopic pancreas in the gastrointestinal tract in children: a single-center experience and a review of the literature

Heterotopic pancreas in the gastrointestinal tract in children: a single-center experience and a review of the literature

Jejunal ectopic pancreas in a neonate

Acinar cell carcinoma of the pancreas in childhood

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