Omental lipoblastoma

Koplin, Stephanie A.; Twohig, Matthew; Lund, Dennis P.; Hafez, G. Reza

doi:10.1016/j.prp.2007.10.004

Cited by 14 publications

(14 citation statements)

References 18 publications

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“…Radiation therapy has been widely used and established to be an efficacious treatment for some tumor types including breast cancer, cervical cancer and uterine cancer. Notably, most documented cases of post-radiation angiosarcomas have been reported in breast, skin and associated soft tissue [17]. In the present study, we have retrospectively detected 28 cases of radiation-induced [18,19], the average interval between radiation exposure and presentation of RSA was approximately 9.5 years and ranged from 4 to 21 years.…”

Section: The Characteristics Of Radiotherapy-induced Splenic Angiosarmentioning

confidence: 93%

Clinical Characteristics and Prognostic Factors of Primary Splenic Angiosarcoma: A Retrospective Clinical Analysis from China

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Primary splenic angiosarcoma is an aggressive malignancy originating from endothelial cells with a particularly poor outcome despite radical therapy. Owing to its extremely low incidence, available data for splenic angiosarcoma are limited. The present study aimed to address this limitation by presenting a thorough retrospective analysis of Chinese primary splenic angiosarcoma patients over a 53-year period (1963-2016). Methods: To determine the characteristics of Chinese primary splenic angiosarcoma and identify factors that impact the outcomes of this histology, we retrospectively retrieved reports of 110 Chinese primary splenic angiosarcoma cases published between 1963-2012. Results: In total, 61 males and 49 females diagnosed with primary splenic angiosarcoma were included in the present study. The median age at diagnosis was 50 years (range 2.5–76 years). Of these patients, 25.5% had received prior radiotherapy. The rate of splenic rupture was 59.11%. The 1-year overall survival rate was 19.1% with a median overall survival time of 8.1 months. Age, gender, and radiation history showed no correlation with survival rate. However, by univariate analysis, we found that significant adverse predictors of survival were splenic rupture before surgery and large tumor size (> 5 cm), while adjuvant chemotherapy was a favorable predictor. Furthermore, multivariate analysis revealed that splenic rupture and adjuvant chemotherapy were independent adverse and favorable predictors, respectively. Conclusion: Our large series describes and confirms the characteristics and poor prognosis of Chinese primary splenic angiosarcoma, thus indicating a critical role for early diagnosis and surgical intervention (prior to rupture) in management, and highlights the promising potential of adjuvant chemotherapy for improving the outcome in these cases.

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Section: The Characteristics Of Radiotherapy-induced Splenic Angiosarmentioning

confidence: 93%

Clinical Characteristics and Prognostic Factors of Primary Splenic Angiosarcoma: A Retrospective Clinical Analysis from China

Zhang

et al. 2018

Cell Physiol Biochem

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“…As radiation is a proved efficacious treatment for some types of tumor including breast cancer, cervical cancer and uterine cancer, therefore, abdominal radiation therapy is widely used. Most of the documented cases of post-radiation angiosarcoma are reported in breast, skin and associated soft tissue [24]. Currently, post-radiation angiosarcoma has also been described in the small bowel, colon and omentum, even in the entire abdomen [25-27].…”

Section: Resultsmentioning

confidence: 99%

Clinical Characteristics and Prognostic Factors of Small Intestine Angiosarcoma: a Retrospective Clinical Analysis of 66 Cases

Ouyang

Xiao

et al. 2017

Cell Physiol Biochem

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Background/Aims: Primary angiosarcoma of the small intestine is a rare neoplasia, and there are limited data from systematic analyses. The aim of this study is to describe the clinical and pathological characteristics in addition to the prognostic factors for this rare neoplasia. Methods: We retrospectively collected the clinical records and prognostic information of 66 patients with small intestine angiosarcoma reported between 1970 and 2017. We used the Chi-square test, the log-rank test, and Cox regression analyses to evaluate the data. Results: There were 66 patients diagnosed with small intestine angiosarcoma. The onset age ranged from 24–92 years old. There were 24 patients diagnosed before the year 2000, and 42 patients were diagnosed after 2000. The data indicated that 49 cases were diagnosed as primary disease, and the remaining 15 cases were secondary disease. The main clinical symptoms were nonspecific and included gastrointestinal (GI) bleeding and abdominal pain. Additionally, we found multi-center foci were one of the characteristics of this disease. Radiation-induced small intestine angiosarcoma (RSIA) is a special type of disease with a similar prognosis. This type was more frequent in females and decreased after the year 2000. We also found that GI bleeding was less common in RSIA cases. The log-rank test results revealed that old-age, poor differentiation, and GI bleeding were associated with worse prognosis. Surgical treatment showed a trend toward a prolonged survival time. However, the result was not statistically significant. Our results show treatment with adjuvant therapy improved prognosis. The multivariate Cox analysis demonstrated adjuvant therapy was an independent indicator of a favorable outcome in small intestine angiosarcoma patients. Conclusion: Pay attention to the unexplained gastrointestinal bleeding could lead to a faster diagnosis and control of small intestine angiosarcoma. Furthermore, treatments including adjuvant therapy can effectively improve the prognosis.

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“…These lesions are usually noted during the first three years of life and are most commonly painless nodules or masses found on the upper and lower extremities (2). Omental lipoblastoma is extremely rare; only 12 cases of omental lipoblastoma have been reported in the English literature (3)(4)(5)(6)(7)(8). With regard to differentiation between lipomas and lipoblastomas, lipomas are rare during the first two decades of life, and unlike lipoblastomas, they are rarely larger than 10 cm (2).…”

Section: Discussionmentioning

confidence: 99%

Successful laparoscopic extirpation of a large omental lipoblastoma in a child

Furukawa

Aoi

Sakai

et al. 2015

Asian J Endoscop Surgery

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Omental lipoblastoma is extremely rare among benign tumors. We herein report the case of a child who underwent laparoscopic extirpation of a large omental lipoblastoma. A 4-year-old girl was diagnosed with an intra-abdominal solid tumor. Abdominal imaging revealed a fat density mass that was well encapsulated and measured 18 × 15 × 7.5 cm in size. Considering the MRI findings and movability of the tumor, we strongly suspected that the lesion was an omental lipoblastoma. We initially decided to perform laparoscopic exploration and, if possible, extirpation of the solid tumor sequentially. A total of five trocars were used, and the tumor was found to originate from the omentum. We successfully performed complete resection of the tumor laparoscopically. A histological examination revealed lipoblastoma. For large abdominal tumors in children, the laparoscopic approach is recommended as the first procedure when the tumor is preoperatively considered to be benign and resectable.

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Omental lipoblastoma

Cited by 14 publications

References 18 publications

Clinical Characteristics and Prognostic Factors of Primary Splenic Angiosarcoma: A Retrospective Clinical Analysis from China

Clinical Characteristics and Prognostic Factors of Primary Splenic Angiosarcoma: A Retrospective Clinical Analysis from China

Clinical Characteristics and Prognostic Factors of Small Intestine Angiosarcoma: a Retrospective Clinical Analysis of 66 Cases

Successful laparoscopic extirpation of a large omental lipoblastoma in a child

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