2024
DOI: 10.1021/acsbiomaterials.3c01877
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Omentum Extracellular Matrix-Silk Fibroin Hydroscaffold Promotes Wound Healing through Vascularization and Tissue Remodeling in the Diabetic Rat Model

Bibrita Bhar,
Priyanka Ranta,
Pavan Kumar Samudrala
et al.

Abstract: Nonhealing diabetic wounds are often associated with significant mortality and cause economic and clinical burdens to the healthcare system. Herein, a biomimetic hydroscaffold is developed using omentum tissue-derived decellularized-extracellular matrix (dECM) and silk fibroin (SF) proteins that associate the behavior of a collagenous fibrous scaffold and a hydrogel to reproduce all aspects of the provisional skin tissue matrix. The chemical cross-linker-free in situ gelation property of the two types of SF pr… Show more

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Cited by 6 publications
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“…Natural biomaterials, such as silk fibroin protein (SF), are gaining attention in wound care research . It is being extensively explored due to its unique properties, including abundant supply, low cost, biodegradability, biocompatibility, and nontoxicity. The studies on SF for flexible electronics and sensing have primarily emphasized its role as a substrate rather than as an active component . Despite possessing favorable characteristics, SF has received limited attention for the development of ionogels.…”
mentioning
confidence: 99%
“…Natural biomaterials, such as silk fibroin protein (SF), are gaining attention in wound care research . It is being extensively explored due to its unique properties, including abundant supply, low cost, biodegradability, biocompatibility, and nontoxicity. The studies on SF for flexible electronics and sensing have primarily emphasized its role as a substrate rather than as an active component . Despite possessing favorable characteristics, SF has received limited attention for the development of ionogels.…”
mentioning
confidence: 99%