Omeprazole Absorption and Fasting Gastrinemia After Roux-en-Y Gastric Bypass

Collares-Pelizaro, Renata V. A.; Santos, José Sebastião dos; Nonino, Carla Barbosa; Gaitani, Cristiane Masetto de; Wilson, Steven E.

doi:10.1007/s11695-017-2672-z

Cited by 17 publications

(17 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of the total 21 studies, some conducted more than one procedure: 19 studies investigated RYGB, five investigated SG, two investigated BPD‐DS, and one study investigated mini‐GB . The number of participants in these studies ranged from five patients in a single study to a maximum of 34 patients.…”

Section: Resultsmentioning

confidence: 99%

“…Most studies provided their data by providing both pre and postoperative T max , C max , and AUC, while others provided a percentage or ratio of change in these values. In two studies, a change in drug plasma concentration was reported. See Appendix S1 for data extraction of included studies.…”

Section: Resultsmentioning

confidence: 99%

“…The drugs investigated in this review were benzodiazepines: midazolam; anti‐arrhythmics: digoxin; corticosteroids: hydrocortisone; hormonal: desogestrel; antidepressants: venlafaxine, escitalopram, duloxetine, citalopram, and sertraline; antihypertensives: metoprolol; lipid‐reducing drugs: fenofibrate, and atorvastatin; anti‐infectives: posaconazole, amoxicillin, and linezolid; analgesics: morphine, and paracetamol; anticoagulant: rivaroxaban; and antiplatelet: aspirin; and acid‐reducing drugs: omeprazole . Amouyal et al included drugs for treatment of human immunodeficiency virus (HIV), namely, the combinations of the antiretroviral drugs: abacavir, atazanavir, efavirenz, emtricitabine, lamivudine, darunavir, raltegravir, ritonavir, and tenofovir …”

Section: Resultsmentioning

confidence: 99%

“…In the included articles, 11 studies reported a statistically significant change in pharmacokinetics before and after a bariatric procedure, measured as a change in either C max , T max , or AUC with statistical significance determined with a P value lower than .05. In six studies, the results were either reported as nonsignificant or the P values presented were above the threshold for statistical significance ( P < .05).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Pharmacokinetic changes post–bariatric surgery: A scoping review

McLachlan

Chaar

2020

Obesity Reviews

View full text Add to dashboard Cite

Summary Bariatric surgeries induce structural changes that can alter the absorption of drugs in patients already at risk of polypharmacy. This scoping review aimed to explore pharmacokinetic changes of orally administered drugs in patients post‐bariatric surgery, and assess the quality and level of bias. Electronic databases were searched for articles relating to bariatric surgery and pharmacokinetics published between 1998 and 2019. Pre‐post studies reporting on pharmacokinetic parameters were included, and the Newcastle‐Ottawa Scale was used to assess risk‐of‐bias. A total of 21 studies were included in this review, and changes in absorption were reported in all included studies across 29 drugs. In 11 studies, this change was reported as statistically significant (p<.05), while six reported a nonsignificant change. More drugs exhibited a shorter Tmax and higher Cmax after surgery than otherwise, however changes in AUC were variable. Four studies were assessed as having fair quality while the remainder of the included studies were of good quality and low risk‐of‐bias. Bariatric surgery alters the absorption of drugs and several mechanisms are implicated to be responsible. Short and long‐term monitoring is recommended in patients post‐surgery for clinical changes in response to medications. Future research with a higher number of participants and greater control of variables, such as concurrent medications, malabsorptive disorders, and body composition should be considered.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacokinetic changes post–bariatric surgery: A scoping review

McLachlan

Chaar

2020

Obesity Reviews

View full text Add to dashboard Cite

show abstract

“…59,60 Gastric acid is needed to digest the minerals from food and solubilize them, so that they are bioavailable for absorption. Moreover, to reduce the risk for stomach ulcers after surgery, patients increase their use of proton pump inhibitors, 132 and hypogastric acidity impairs the absorption of nutrients. 133 Bypass of the proximal intestine, which is where the majority of the transporters of minerals are located, also contributes to the reduced absorption of iron, 105 zinc, 105 and vitamin D 134 that has been observed after surgery.…”

Section: Impact On Micronutrient Statusmentioning

confidence: 99%

Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut

Jain

Roux

Puri

et al. 2018

J Parenter Enteral Nutr

View full text Add to dashboard Cite

The goal of the National Institutes of Health-funded American Society for Parenteral and Enteral Nutrition 2017 research workshop (RW) "Gastric Bypass: Role of the Gut" was to focus on the exciting research evaluating gut-derived signals in modulating outcomes after bariatric surgery. Although gastric bypass surgery has undoubted positive effects, the mechanistic basis of improved outcomes cannot be solely explained by caloric restriction. Emerging data suggest that bile acid metabolic pathways, luminal contents, energy balance, gut mucosal integrity, as well as the gut microbiota are significantly modulated after bariatric surgery and may be responsible for the variable outcomes, each of which was rigorously evaluated. The RW served as a timely and novel academic meeting that brought together clinicians and researchers across the scientific spectrum, fostering a unique venue for interdisciplinary collaboration among investigators. It promoted engaging discussion and evolution of new research hypotheses and ideas, driving the development of novel ameliorative, therapeutic, and nonsurgical interventions targeting obesity and its comorbidities. Importantly, a critical evaluation of the current knowledge regarding gut-modulated signaling after bariatric surgery, potential pitfalls, and lacunae were thoroughly addressed.

show abstract

Systematic review of drug bioavailability following gastrointestinal surgery

Santamaría

Villafranca

Abilés

et al. 2018

Eur J Clin Pharmacol

View full text Add to dashboard Cite

Modifications in the digestive tract secondary to gastrointestinal surgery may compromise the bioavailability of drugs. Decreased absorption surface, gastric emptying speed, and gastric pH alteration are factors to be taken into account in the management of pharmacological treatment after surgery. Evidence supported by data in clinical practice is scarce, but after studying the pharmacokinetic profile of some molecules, it is possible to offer recommendations for its adaptation to the patient's clinical situation.

show abstract

Omeprazole Absorption and Fasting Gastrinemia After Roux-en-Y Gastric Bypass

Abstract: The standard OME dose (40 mg) administered after bariatric surgery is insufficient to achieve serum levels that can effectively block the production of hydrochloric acid, permitting the formation of peptic injuries in many patients.

Cited by 17 publications

References 21 publications

Pharmacokinetic changes post–bariatric surgery: A scoping review

Pharmacokinetic changes post–bariatric surgery: A scoping review

Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut

Systematic review of drug bioavailability following gastrointestinal surgery

Contact Info

Product

Resources

About