Omeprazole Absorption from a Compounded Transdermal Formulation in Healthy Volunteers

Haas, Curtis E.; Lin, Lydia; Cloen, Denise; Kufel, Thomas J.; Moon, Richard C.; Frerichs, Valerie

doi:10.1331/1544345054475603

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Less optimistic data were presented by Haas et al [ 316 ], who conducted a clinical study on the bioavailability of omeprazole after transdermal administration. The tested formulation was a pleuronic lecithin organogel (PLO) with an omeprazole concentration of 50 mg/mL.…”

Section: Development Of New Formulations With Ppismentioning

confidence: 99%

“…An amount of gel equivalent to 40 mg of the drug substance was administered to the skin of the forearm without an occlusive dressing to 8 healthy volunteers. It was shown that the transdermal form of the drug was not bioequivalent to the oral capsule and that the permeability of the drug through the skin was poor [ 316 ].…”

Section: Development Of New Formulations With Ppismentioning

confidence: 99%

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Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives

2022

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Since their introduction to pharmacotherapy, proton pump inhibitors (PPIs) have been widely used in the treatment of numerous diseases manifested by excessive secretion of gastric acid. Despite that, there are still unmet needs regarding their availability for patients of all age groups. Their poor stability hinders the development of formulations in which dose can be easily adjusted. The aim of this review is to describe the discovery and development of PPIs, discuss formulation issues, and present the contemporary solutions, possibilities, and challenges in formulation development. The review outlines the physicochemical characteristics of PPIs, connects them with pharmacokinetic and pharmacodynamic properties, and describes the stability of PPIs, including the identification of the most important factors affecting them. Moreover, the possibilities for qualitative and quantitative analysis of PPIs are briefly depicted. This review also characterizes commercial preparations with PPIs available in the US and EU. The major part of the review is focused on the presentation of the state of the art in the development of novel formulations with PPIs covering various approaches employed in this process: nanoparticles, microparticles, minitablets, pellets, bilayer, floating, and mucoadhesive tablets, as well as parenteral, transdermal, and rectal preparations. It also anticipates further possibilities in the development of PPIs dosage forms. It is especially addressed to the researchers developing new formulations containing PPIs, since it covers the most important formulary issues that need to be considered before a decision on the selection of the formula is made. It may help in avoiding unnecessary efforts in this process and choosing the best approach. The review also presents an up-to-date database of publications focused on the pharmaceutical technology of formulations with PPIs.

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Section: Development Of New Formulations With Ppismentioning

confidence: 99%

Section: Development Of New Formulations With Ppismentioning

confidence: 99%

Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives

2022

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“…Analogously, pharmacokinetic studies evaluating plasma concentrations with various formulations of omeprazole concluded that transdermal gel formulation was not bioequivalent to the oral capsule formulation. 3 Additionally, Smith et al 2 suggested that alternative mechanisms should be explored to explain the perceived efficacy of ABH gel, because transdermal absorption leading to nil-to-minimal or subtherapeutic blood concentrations of active ingredients does not explain the role of ABH gel in the treatment of nausea–vomiting. Herein, we discuss possible mechanisms that may explain ABHR transdermal gel’s efficacy.…”

mentioning

confidence: 99%

A Physiological Perspective for Utility or Futility of Alcohol-Based Hand Rub Gel Against Nausea–Vomiting

Gupta

Mazumdar

Stellini

2013

Am J Hosp Palliat Care

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Nausea-vomiting is a common and unpleasant phenomenon with numerous underlying mechanisms and pathways that are not always well elucidated. In clinical practice, refractory nausea-vomiting is encountered in several settings. Antiemetic medications may reduce these symptoms but are not always effective in all patients. In the absence of a well-defined optimal strategy for management of nausea-vomiting, the search for better approaches to treat this distressing symptom continues. One of the alternative treatment approaches is a compounded formulation called ABHR gel that is comprised of multiple antiemetic medications and has been shown to be useful for symptomatic relief in some patients with refractory nausea-vomiting. It has been suggested that alternative mechanisms should be explored to explain the perceived efficacy of ABHR gel, because transdermal absorption leading to nil-to-minimal or subtherapeutic blood concentrations of active ingredients does not explain the role of ABHR gel in the treatment of nausea-vomiting. In the current paper, we discuss possible mechanisms that may explain ABHR transdermal gel's efficacy. Compounded ABHR transdermal gel formulation's efficacy in antagonizing nausea-vomiting that has been recently questioned may be explained by alternative mechanisms mediated through the P-6 acupoint stimulation and facial-nasal, cooling-related counterstimulation.

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Nanostructured lipid carriers for transdermal delivery of acid labile lansoprazole

Lin

Duh

2016

European Journal of Pharmaceutics and Biopharmaceutics

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Omeprazole Absorption from a Compounded Transdermal Formulation in Healthy Volunteers

Cited by 4 publications

References 15 publications

Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives

Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives

A Physiological Perspective for Utility or Futility of Alcohol-Based Hand Rub Gel Against Nausea–Vomiting

Nanostructured lipid carriers for transdermal delivery of acid labile lansoprazole

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