Omeprazole reduces the response to capsaicin but not to methacholine in asthmatic patients with proximal reflux

Ferrari, Marcello; Benini, Luigi; Brotto, Emanuele; Locatelli, Francesca; Iorio, Fosca De; Bonella, Francesco; Tacchella, N.; Corradini, G.G.; Cascio, Vincenzo Lo; Vantini, Italo

doi:10.1080/00365520600883777

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…In this regard, Ferrari and colleagues studied 17 patients with asthma and proximal reflux. They found that omeprazole reduced the cough sensitivity to capsaicin but did not alter airways reactivity to methacholine (28). Interestingly, previous studies have demonstrated that proximal acid reflux is predictive of a favorable response to acid suppressor therapy, although we did not find this in our trial (2,29).…”

Section: Discussioncontrasting

confidence: 76%

Effects of Asymptomatic Proximal and Distal Gastroesophageal Reflux on Asthma Severity

DiMango¹,

Holbrook²,

Simpson³

et al. 2009

Am J Respir Crit Care Med

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Asymptomatic GER is not associated with distinguishing asthma symptoms or lower lung function in individuals with suboptimal asthma control who are using inhaled corticosteroids. Patients with proximal reflux report significantly worse asthma and health-related quality of life despite lack of physiologic impairment or increase in asthma symptoms. Clinical trial registered with www.clinicaltrials.gov (NCT00069823).

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Section: Discussioncontrasting

confidence: 76%

Effects of Asymptomatic Proximal and Distal Gastroesophageal Reflux on Asthma Severity

DiMango¹,

Holbrook²,

Simpson³

et al. 2009

Am J Respir Crit Care Med

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“…Both have been recommended [Pratter et al 2006] and are widely used for a variety of airway reflux manifestations. There is some evidence of an effect, for instance a reduction in capsaicin cough sensitivity with omeprazole was demonstrated in patients with asthma [Ferrari et al 2007] but a recent randomised trial showed no effect of PPIs in poorly controlled asthma [Mastronarde et al 2009]. The authors concluded that reflux was not a significant contributor to poor asthma control, however the study proves only that acid reflux is not relevant.…”

Section: Pharmacological Agentsmentioning

confidence: 99%

Airway reflux, cough and respiratory disease

Molyneux

Morice

2011

Therapeutic Advances in Chronic Disease

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It is increasingly accepted that the effects of gastro-oesophageal reflux are not limited to the gastrointestinal tract. The adjacent respiratory structures are also at risk from material ejected from the proximal oesophagus as a result of the failure of anatomical and physiological barriers. There is evidence of the influence of reflux on several respiratory and otorhinological conditions and although in many cases the precise mechanism has yet to be elucidated, the association alone opens potential novel avenues of therapy to clinicians struggling to treat patients with apparently intractable respiratory complaints. This review provides a description of the airway reflux syndrome, its effects on the lung and current and future therapeutic options.

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“…Selectivity of TRPV1 regulation by acidic-induced inflammation is suggested by the observation that in asthmatics inhibition of gastric acid secretion does not influence bronchial hyperresponsiveness to methacholine, but decreases tussive sensitivity to capsaicin and this effect is related to proximal reflux (Ferrari et al 2007). The interaction between sensory nerve supply with the inflamed or injured tissue may follow nonobvious anatomical circuitry as acid instillation in the esophagus acutely increases the cough reflex sensitivity to capsaicin in patients with gastroesophageal reflux disease and chronic cough (Javorkova et al 2008).…”

Section: Discussionmentioning

confidence: 97%

Cough Sensors. II. Transient Receptor Potential Membrane Receptors on Cough Sensors

Materazzi

Nassini

Gatti

et al. 2009

Pharmacology and Therapeutics of Cough

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The transient receptor potential (TRP) family of channels is represented by at least six members in primary sensory neurons. These include the TRP vanilloid subtypes 1 (TRPV1), 2, 3, and 4, the cold and menthol receptor TRPM8, and TRPA1. Much interest has been directed to the study of the TRPV1, because capsaicin has been instrumental in discovering the unique role of a subset of primary sensory neurons in causing nociceptive responses, in activating reflex pathways including cough, and in producing neurogenic inflammation. TRPV1 is now regarded as an integrator of diverse sensory modalities because it undergoes marked plasticity and sensitization through a variety of mechanisms, including activation of G-protein-coupled or tyrosine kinase receptors. Evidence in experimental animals and in patients with airway diseases indicates a marked hypersensitivity to cough induced by TRPV1 agonists. Recent studies with newly developed high-affinity and selective TRPV1 antagonists have revealed that TRPV1 inhibition reduces cough induced by citric acid or antigen challenge.

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Omeprazole reduces the response to capsaicin but not to methacholine in asthmatic patients with proximal reflux

Abstract: In asthmatics, inhibition of gastric acid secretion does not influence bronchial hyperresponsiveness but decreases tussive sensitivity and this effect is related to proximal reflux.

Cited by 12 publications

References 45 publications

Effects of Asymptomatic Proximal and Distal Gastroesophageal Reflux on Asthma Severity

Effects of Asymptomatic Proximal and Distal Gastroesophageal Reflux on Asthma Severity

Airway reflux, cough and respiratory disease

Cough Sensors. II. Transient Receptor Potential Membrane Receptors on Cough Sensors

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