Omeprazole treatment diminishes intra- and extracellular neutrophil reactive oxygen production and bactericidal activity*

Zedtwitz-Liebenstein, Konstantin; Wenisch, Christoph; Patruta, Sandra; Parschalk, Berhard; Daxböck, Florian; Graninger, Wolfgang

doi:10.1097/00003246-200205000-00026

Cited by 198 publications

(137 citation statements)

References 38 publications

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“…The humoral defense mechanism against bacterial colonization is mediated by the white blood cells. In vitro studies [43][44][45] have assessed the cytotoxicity of natural killer (NK) cells when exposed to target cells in varying ratios and in different solution media. Not surprisingly, as the ratio of NK cells to target cells increased, the percentage of target cells lysed increased, suggesting a positive correlation.…”

Section: Ppis and Pneumonia-pathophysiologymentioning

confidence: 99%

Proton pump inhibitor-associated pneumonia: Not a breath of fresh air after all?

Fohl

Regal²

2011

WJGPT

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Over the past two decades, proton pump inhibitors (PPIs) have emerged as highly effective and relatively safe agents for the treatment of a variety of gastrointestinal disorders. Unfortunately, this desirable pharmacological profile has also contributed to superfluous and widespread use in both the inpatient and outpatient settings. While generally well-tolerated, research published over the last decade has associated these agents

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Section: Ppis and Pneumonia-pathophysiologymentioning

confidence: 99%

Proton pump inhibitor-associated pneumonia: Not a breath of fresh air after all?

Fohl

Regal²

2011

WJGPT

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“…It is possible that in humans, if the conversion of C. difficile to the vegetative phase occurs while spores are still in the stomach their survival may be facilitated by elevated gastric pH levels. Alternatively other mechanisms, such as PPI-induced increased gastrin-mediated direct effect on colonic mucosa (9), effect on immune function (21) or effects on the organism's toxin production (5) may also be possible.…”

Section: Comparative Role Of Antibiotic and Proton Pump Inhibitor In mentioning

confidence: 99%

Comparative Role of Antibiotic and Proton Pump Inhibitor in Experimental Clostridium difficile Infection in Mice

Kaur

Vaishnavi

Prasad

et al. 2007

Microbiology and Immunology

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Clostridium difficile inoculated BALB/c mice were investigated to assess the comparative role of antibiotic and proton pump inhibitor. They were examined for colonization and toxin production by C. difficile as well as myeloperoxidase activity and histopathological changes in the intestinal tract. The C. difficile count, toxin A and B titres and myeloperoxidase activity were significantly higher (P>0.05) in ampicillin and lansoprazole receiving groups as compared to the control and the C. difficile receiving groups. Similarly they showed significant difference (P>0.05) for epithelial damage, oedema and neutrophilic infiltrate in colons. In addition to antibiotic, PPI also acts as an independent risk factor for C. difficile infection in experimental studies.

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“…A pesar de esto, la espora de C. difficile es relativamente estable frente al ácido gástrico, por lo que la explicación fisiopatológica para la asociación entre el uso de supresores de ácido y la infección por C. difficile no es del todo clara. Como factores que también pueden predisponer a esta infección, se han postulado la alteración de la flora intestinal, el efecto directo del germen sobre la actividad de los leucocitos (29,30), y la disminución en la expresión de genes con importantes funciones en la integridad del colonocito y en la sensibilidad a la toxina (31). En un metaanálisis en el cual se incluyeron 288.620 pacientes, Janarthanan, et al (15), encontraron una asociación entre el uso de inhibidores de la bomba de protones y la infección por C. difficile, con un riesgo relativo de 1,65 (IC 95% 1,41-1,93).…”

Section: Discussionunclassified

Clinical and demographic profile and risk factors for Clostridium difficile infection

Carvajal¹,

Pacheco²,

Jaimes³

2017

biomedica

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Contribución de los autores:Todos los autores participaron en igual medida en todos los aspectos del estudio y la redacción del manuscrito. Introducción. La enfermedad asociada a Clostridium difficile es la principal causa de diarrea infecciosa adquirida en el hospital; su creciente incidencia, las menores tasas de respuesta al tratamiento inicial y la mayor tasa de recaídas han incrementado la carga de la enfermedad. Objetivo. Determinar las características clínicas de los pacientes hospitalizados con enfermedad asociada a C. difficile. Materiales y métodos. Se hizo un estudio de casos anidado en una cohorte. Se revisaron las historias clínicas de pacientes con diarrea iniciada durante su hospitalización a quienes se les había practicado la prueba de detección de la toxina A-B de C. difficile, entre febrero de 2010 y febrero de 2012. Se definió como caso al paciente hospitalizado con diarrea y prueba de Enzyme Linked Fluorescent Assay (ELFA) positiva para la toxina y, como control, a aquel con resultado negativo para la toxina. Se recolectaron los datos demográficos y clínicos, así como la información sobre los factores asociados, la estancia hospitalaria, el tratamiento y las complicaciones. Perfil clínico y demográfico y factores de riesgo frente a la infección por Clostridium difficileResultados. Durante el periodo de seguimiento se recolectaron datos de 123 pacientes, de los cuales 30 fueron positivos para la toxina. La edad media en la población de estudio fue de 49 años y el 60 % correspondía a hombres. Los síntomas predominantes fueron el dolor abdominal (35 %) y la fiebre (34 %). Las principales complicaciones fueron la alteración electrolítica y la sepsis grave asociada con disfunción renal. La mortalidad total fue de 13 % y los factores independientes asociados con la aparición de la infección fueron el uso de inhibidores de la bomba de protones y la cirugía gastrointestinal previa. Conclusiones. El uso de inhibidores de la bomba de protonesy la cirugía gastrointestinal previa fueron factores asociados con la infección por C. difficile. Clinical and demographic profile and risk factors for Clostridium difficile infectionIntroduction: Clostridium difficile infection is the leading cause of nosocomial infectious diarrhea. The increasing incidence added to a lower rate of response to the initial treatment and higher rates of relapse has generated a higher burden of the disease. Objective: To determine the clinical characteristics of hospitalized patients with C. difficile infection. Materials and methods:We made a nested case-cohort study. We reviewed medical records of the patients with nosocomial diarrhea for whom an assay for toxin A-B of C. difficile had been requested from February, 2010, to February, 2012. We defined case as a patient with diarrhea and a positive assay for the toxin, and control as those patients with a negative assay for the toxin. We collected data on demographic and clinical characteristics, risk factors, hospital length of stay, treatment, and complications. Results: We collec...

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Omeprazole treatment diminishes intra- and extracellular neutrophil reactive oxygen production and bactericidal activity*

Cited by 198 publications

References 38 publications

Proton pump inhibitor-associated pneumonia: Not a breath of fresh air after all?

Proton pump inhibitor-associated pneumonia: Not a breath of fresh air after all?

Comparative Role of Antibiotic and Proton Pump Inhibitor in Experimental Clostridium difficile Infection in Mice

Clinical and demographic profile and risk factors for Clostridium difficile infection

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