Omicron and S‐gene target failure cases in the highest COVID‐19 case rate region in Canada—December 2021

Li, Anthony; Maier, Allison; Carter, Megan; Guan, T Hugh

doi:10.1002/jmv.27562

Cited by 37 publications

(39 citation statements)

References 2 publications

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“…In the Kingston, Frontenac, Lennox & Addington (KFL&A) region of Canada, initial modelling estimated revealed the Re for Omicron at 1.5 (A. Li et al, 2021 ). The emergence of Omicron variant has raised high concerns owing it to be a most mutated SARS-CoV-2 variant with nearly 50 mutations being gathered in its genome and mainly because it had at least 30 mutations in the viral spike (S) region, particularly at the receptor binding domain (RBD).…”

Section: Major Public Health Concerns Related To Omicronmentioning

confidence: 99%

“…spatiotemporal distribution of airborne pathogens is determined using computational fluid dynamics (CFD) simulations of airflow and aerosol transport and it revealed that a combination of proper ventilation along with PPE kit are necessary for preventing the transmission risk at hospital wards (X. Li et al, 2021 ). Experts suggest that the governments should implement strict restrictions based on modelling, which indicates that without posing additional restrictions, hospital admission could peak 3000 and 10000 a day, with a death toll between 600 and 6000 a day ( Iacobucci, 2021b ).…”

Section: What Can Be Done In the Present Scenario?mentioning

confidence: 99%

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Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

Khandia

Singhal

Alqahtani

et al. 2022

Environmental Research

248

196

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Since the appearance in the late of December 2019, SARS-CoV-2 is rapidly evolving and mutating continuously, giving rise to various variants with variable degrees of infectivity and lethality. The virus that initially appeared in China later mutated several times, wreaking havoc and claiming many lives worldwide amid the ongoing COVID-19 pandemic. After Alpha, Beta, Gamma, and Delta variants, the most recently emerged variant of concern (VOC) is the Omicron (B.1.1.529) that has evolved due to the accumulation of high numbers of mutations especially in the spike protein, raising concerns for its ability to evade from pre-existing immunity acquired through vaccination or natural infection as well as overpowering antibodies-based therapies. Several theories are on the surface to explain how the Omicron has gathered such a high number of mutations within less time. Few of them are higher mutation rates within a subgroup of population and then its introduction to a larger population, long term persistence and evolution of the virus in immune-compromised patients, and epizootic infection in animals from humans, where under different immune pressures the virus mutated and then got reintroduced to humans. Multifaceted approach including rapid diagnosis, genome analysis of emerging variants, ramping up of vaccination drives and receiving booster doses, efficacy testing of vaccines and immunotherapies against newly emerged variants, updating the available vaccines, designing of multivalent vaccines able to generate hybrid immunity, up-gradation of medical facilities and strict implementation of adequate prevention and control measures need to be given high priority to handle the on-going SARS-CoV-2 pandemic successfully.

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Section: Major Public Health Concerns Related To Omicronmentioning

confidence: 99%

Section: What Can Be Done In the Present Scenario?mentioning

confidence: 99%

Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

Khandia

Singhal

Alqahtani

et al. 2022

Environmental Research

248

196

View full text Add to dashboard Cite

show abstract

“…The most common symptoms reported in confirmed cases of the Omicron variant infection are nasal congestion (73%), cough (65%), headaches (54%), sore throat (48%), chills (34%), and fever (32%). Only 10% reported shortness of breath, and most asymptomatic patients were vaccinated [45].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Omicron Genetic and Clinical Peculiarities That May Overturn SARS-CoV-2 Pandemic: A Literature Review

Tiecco

Storti

Antoni

et al. 2022

IJMS

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The Coronavirus disease 2019 (COVID-19) pandemic poses a great threat to global public health. The original wild-type strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has genetically evolved, and several variants of concern (VOC) have emerged. On 26 November 2021, a new variant named Omicron (B.1.1.529) was designated as the fifth VOC, revealing that SARS-CoV-2 has the potential to go beyond the available therapies. The high number of mutations harboured on the spike protein make Omicron highly transmissible, less responsive to several of the currently used drugs, as well as potentially able to escape immune protection elicited by both vaccines and previous infection. We reviewed the latest publication and the most recent available literature on the Omicron variant, enlightening both reasons for concern and high hopes for new therapeutic strategies.

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“…A deletion at position 69-70 in the spike (S) gene of Omicron variant leads to a loss of detection of this target in the TaqPath assay and allows the discrimination with the Delta variant (Omicron: S-/ Delta: S + ) . 8 The TaqPath profiles and whole genome sequences (PacBio technology) of a subset of 560 positive specimens were 100% concordant. Viral loads (log 10 copies/ml) were determined using a calibration curve obtained with the TaqPath N gene Ct values and digital droplet RT-PCR (RT-ddPCR) (BioRad, Hercules, CA).…”

mentioning

confidence: 94%

Influence of immune escape and nasopharyngeal virus load on the spread of SARS-CoV-2 Omicron variant

Migueres

Dimeglio

Trémeaux

et al. 2022

Journal of Infection

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Omicron and S‐gene target failure cases in the highest COVID‐19 case rate region in Canada—December 2021

Cited by 37 publications

References 2 publications

Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

Omicron Genetic and Clinical Peculiarities That May Overturn SARS-CoV-2 Pandemic: A Literature Review

Influence of immune escape and nasopharyngeal virus load on the spread of SARS-CoV-2 Omicron variant

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