2022
DOI: 10.1016/j.ijbiomac.2022.07.254
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Omicron (B.1.1.529) - A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoprotein

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Cited by 49 publications
(23 citation statements)
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“…Efforts are being made over time to develop the next-generation vaccine and mutation-proof vaccines [ 28 , 140 , 141 ]. At the same time, it has been observed that the Omicron variant and its sub-variant possess a very high number of mutations [ 27 , 29 , 120 ]. These mutations provide three significant properties to the Omicron variant.…”
Section: Discussionmentioning
confidence: 99%
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“…Efforts are being made over time to develop the next-generation vaccine and mutation-proof vaccines [ 28 , 140 , 141 ]. At the same time, it has been observed that the Omicron variant and its sub-variant possess a very high number of mutations [ 27 , 29 , 120 ]. These mutations provide three significant properties to the Omicron variant.…”
Section: Discussionmentioning
confidence: 99%
“…Several mutations have been observed in the newly developed variants which alter the binding region of nAb, leading to antibody escape [ 117 , 118 ]. In the Omicron case, several mutations have been noted in the nAb binding region of the S protein, especially in RBD and NTD, which cause the nAb escape phenomenon [ 13 , 19 , 27 , 28 , 29 , 119 , 120 ]. Therefore, we can say that the Omicron variant possesses a partial vaccine escape ability.…”
Section: Immune Escape Of Emerging Omicron Variant and Its Sub-variantmentioning
confidence: 99%
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“…As of 8 September 2021, 1449 3D macro-molecular structural forms of SARS-CoV-2 have been solved and deposited in PDB. SARS-CoV-2 variants are developing due to diversified mutations [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. During the SARS-CoV-2 mutation, the robustness and plasticity of the proteins change, which affects the overall functionality of the domains, especially the functional mechanisms of proteins [ 30 ].…”
Section: Introductionmentioning
confidence: 99%
“…Among them, seven mutations are from RBD and one from outside RBD. The seven RBD mutations are G496S, S477N, K417N, E484A, Q493K, Y505H, and N501Y, and the one outside RBD mutation is D614G [ 6 ]. Chen et al also found mutational escape of the Omicron variant.…”
mentioning
confidence: 99%