2023
DOI: 10.3389/fimmu.2023.1166589
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Omicron infection-associated T- and B-cell immunity in antigen-naive and triple-COVID-19-vaccinated individuals

Abstract: Since early 2022, various Omicron variants have dominated the SARS-CoV-2 pandemic in most countries. All Omicron variants are B-cell immune escape variants, and antibodies induced by first-generation COVID-19 vaccines or by infection with earlier SARS-CoV-2 variants largely fail to protect individuals from Omicron infection. In the present study, we investigated the effect of Omicron infections in triple-vaccinated and in antigen-naive individuals. We show that Omicron breakthrough infections occurring 2–3.5 m… Show more

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Cited by 10 publications
(3 citation statements)
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“…Our study has strengths and limitations. First, we present detailed, in-depth immunological profiles of patients hospitalized with severe COVID-19 at admission, providing valuable insights into the immune responses of vaccinated and non-vaccinated individuals otherwise underreported in the literature ( 50 , 51 ). In contrast to other reports ( 48 , 49 ), we did not only focus on specific immune cells but had a rather broad approach with data on cytokine profiles, B cells, T cells, and T cell receptor profiles, activation, and exhaustion.…”
Section: Discussionmentioning
confidence: 99%
“…Our study has strengths and limitations. First, we present detailed, in-depth immunological profiles of patients hospitalized with severe COVID-19 at admission, providing valuable insights into the immune responses of vaccinated and non-vaccinated individuals otherwise underreported in the literature ( 50 , 51 ). In contrast to other reports ( 48 , 49 ), we did not only focus on specific immune cells but had a rather broad approach with data on cytokine profiles, B cells, T cells, and T cell receptor profiles, activation, and exhaustion.…”
Section: Discussionmentioning
confidence: 99%
“…Following omicron breakthrough infection, there is a durable reprogramming of neutralizing antibody responses, with a robust boosting of neutralization activity and an expansion of breadth against other omicron strains [ 23 ]. In HCWs, the responses to breakthrough omicron infection occurring after three doses are mainly due to cross-reacting B cells initially induced by vaccination, which generate B-cells that bind both the omicron and Wuhan spike proteins [ 24 ]. SARS-CoV-2 vaccines also elicit highly cross-reactive cellular immunity against the omicron variant, providing considerable protection against severe disease [ 25 ].…”
Section: Discussionmentioning
confidence: 99%
“…Omicron is a variant of B cell immunity escape [Barros-Martins et al, 2023]. However, some roles of B cells are yet to be exposed, which are capable of obstructing the contagion.…”
Section: Immune Response In Omicron Wavementioning
confidence: 99%