2024
DOI: 10.1038/s41598-023-50822-w
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Omicron-specific and bivalent omicron-containing vaccine candidates elicit potent virus neutralisation in the animal model

Asghar Abdoli,
Hamidreza Jamshidi,
Mohammad Taqavian
et al.

Abstract: Omicron variant (B.1.1.529) is able to escape from naturally acquired and vaccine-induced immunity, which mandates updating the current COVID-19 vaccines. Here, we investigated and compared the neutralising antibody induction of the ancestral variant-based BIV1-CovIran vaccine, the Omicron variant-based BIV1-CovIran Plus vaccine, and the novel bivalent vaccine candidate, BBIV1-CovIran, against the Omicron and ancestral Wuhan variants on the rat model. After inactivating the viral particles, the viruses were pu… Show more

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