Omission of Early Thromboprophylaxis and Mortality in Critically Ill Patients

Stratified Meta-Analysis of Intermittent Pneumatic Compression of the Lower Limbs to Prevent Venous Thromboembolism in Hospitalized Patients

“…3,4 IPC is an attractive option of thromboprophylaxis because it is applicable to almost all hospitalized patients, including those who have active bleeding or an increased risk of bleeding. Our results showed that IPC was superior to TEDS in reducing the risk of DVT; thus, for patients who are at high risk of bleeding, IPC will be a useful bridging measure until the risk of bleeding is deemed to be acceptable for initiation of pharmacological thromboprophylaxis.…”

“…Although underuse of thromboprophylaxis in many situations has improved with education and automated electronic alert systems, recent studies have shown that many hospitalized patients at risk of venous thromboembolism remained not treated with thromboprophylaxis in a timely fashion. 3,4 Because bleeding from antithrombotic agents is a strong predictor of mortality, many clinicians perceive that the risk of bleeding from pharmacological thromboprophylaxis is more important than the risk of venous thromboembolism, and this contributes to the underuse of early thromboprophylaxis. 5,6 Clinical Perspective on p 1020…”

Bleeding Risk and Thromboprophylaxis in Neurosurgical Patients after Emergency Procedure

“…In addition to VTE risk, mortality rates have also been stratified with VTE prophylaxis in mind, and institution of DVT prophylaxis results in decreased mortality risk [3][4][5]. Multiple case reports and series on postoperative thromboembolic prophylaxis have been published, however clear guidelines for a "Best Practice" have yet to be described [6][7][8].…”

Preventing Venous Thromboembolism in Adults

“…2 Critically ill patients who receive VTE prophylaxis have a significantly lower risk of death than do those who do not receive VTE prophylaxis. 3,4 In a recent study, the incidence of deep vein thrombosis (DVT) in critically ill patients without prophylaxis was 11%. 5 Expected Nursing Practice 1.…”

“…6 Most critically ill patients have 1 or more major risk factors. 3,4,6,7 Researchers in one study 8 examined the incidence of upper-extremity DVT in medical patients and reported that upper-extremity DVT accounted for 51% of the hospital-associated DVTs and that the use of CVCs was a major risk factor. A metaanalysis indicated that PICCs were associated with higher risk of DVT than CVCs in critically ill patients and patients with cancer.…”