“…In the last 15 years, p-B fusion has been effectively induced by means of high-power lasers, which has reported an impressive progression in the reaction yield [2,4,7,8], thus has become a point of interest for the energy sector where it is being considered as an alternative approach to conventional inertial confinement fusion schemes [9][10][11] and also potentially for medicine where intense α-particle beams can be used for radioisotope production [12]. However, an extensive systematic investigation of laser-based p-B fusion of the deep understanding of the underpinning physics is still missing [13]. An overview of the recent experimental progression in p-B fusion in terms of α-particle flux (or flux per input laser energy) is shown in Figure 1, both for the "in-target" [2][3][4]7,14] and "pitcher-catcher" geometries [5,6,8,15].…”