In this study, a multipoint boundary value problem for Volterra-Fredholm integro-differential equations is considered. The addition of a new function converts the system of Volterra-Fredholm integro-differential equations to a system of Fredholm integro-differential equations. In contrast to the original problem, the dimension of a Fredholm integro-differential equation is determined by the number of matrices in the degenerate kernel of the Volterra integral. A numerical algorithm of Dzhumabaev parameterization method for addressing a multipoint boundary value problem for Volterra-Fredholm integro-differential equations is proposed. The main advantage of the proposed method is splitting the problem into auxiliary Cauchy problems for ordinary differential equations and a system of algebraic equations with respect to the parameters. The conditions for the unique solvability of the multipoint boundary value problem for Fredholm integro-differential equations are established. Finally, various numerical examples are provided to demonstrate the efficiency and correctness of the suggested technique.