On a pseudo‐rebreathing technique to assess the ventilatory sensitivity to carbon dioxide in man.

Abstract

SUMMARY1. The ventilatory sensitivity to carbon dioxide obtained from a step-ramp CO2 challenge was compared to the CO2 sensitivity from the steady-state method.2. Experiments were performed in nine healthy male subjects against a background of hyperoxia and in two subjects against a background of normoxia.3. In each subject experiments were performed in which the stepwise increase in

Carbonic anhydrase and control of breathing: different effects of benzolamide and methazolamide in the anaesthetized cat.

“…The mass balance equation for C02 of a brain compartment can be written as (Read & Leigh, 1967;Berkenbosch et al 1989 The cerebral blood flow is assumed to be coupled to Pt co2 in a hyperbolic fashion, with the shape factor a and the asymptote b (cf. Dahan, Berkenbosch, DeGoede, Olievier & Bovill, 1990…”

The influence of oxygen on the ventilatory response to carbon dioxide in man.

“…The magnitude of the normoxic central time constants is roughly three times larger than would be expected from the magnitude of the cerebral blood flow (cf. Dahan, Berkenbosch, DeGoede, Olievier & Bovill, 1990). This may be due to the existence of neuronal dynamics (Eldridge, 1977;Eldridge, Kiley & Paydarfar, 1987;Teppema, Vis, Evers & Folgering, 1982).…”

Inhaled carbon dioxide causes dose-dependent paradoxical bradypnea in animals anesthetized with pentobarbital, but not with isoflurane or ketamine

“…It is likely that the physiological response to changes in inspired CO 2 is affected by the rate of change of inspired gas, and that the step-wise change used in this study may not reflect either a gradual steady-state method or a rebreathing technique, such as Read's method (Berkenbosch et al, 1989;Dahan et al, 1990). This has been attributed, in part, to the effect of the rate of induction of hypercapnia on the sensitivity of cerebral blood flow response (Pandit et al, 2003).…”