In this paper, we study the existence of solutions for a new class of fractional q-integro-difference equations involving Riemann-Liouville q-derivatives and a q-integral of different orders, supplemented with boundary conditions containing q-integrals of different orders. The first existence result is obtained by means of Krasnoselskii's fixed point theorem, while the second one relies on a Leray-Schauder nonlinear alternative. The uniqueness result is derived via the Banach contraction mapping principle. Finally, illustrative examples are presented to show the validity of the obtained results. The paper concludes with some interesting observations. Keywords: q-integro-difference equation; boundary value problem; existence; fixed pointwhere f ∈ C([0, 1] × R, R), c D α q is the fractional q-derivative of the Caputo type, and α i , β i , γ i , η i ∈ R, i = 1, 2.