On acid-base effects of albumin

Krbec, Martin; Koudelková, Kateřina; Duška, František

doi:10.1080/03007995.2021.1944074

Cited by 14 publications

(5 citation statements)

References 3 publications

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“…At physiologic pH this protein is a weak acid with a negative net molecular charge (isoelectric point of BSA is 4,5) [17] . It is found in literature that high concentrations of BSA decrease the buffering capacity of blood [18] . Possibly, this indicates that protein acidity favors the hydrolysis of TMS‐PhE.…”

Section: Resultsmentioning

confidence: 98%

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Lipase‐Mediated Conversion of Protecting Group Silyl Ethers: An Unspecific Side Reaction

Pick,

Wenzlaff,

Yousefi

et al. 2023

ChemBioChem

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Silyl ether protecting groups are important tools in organic synthesis, ensuring selective reactions of hydroxyl functional groups. Enantiospecific formation or cleavage could simultaneously enable the resolution of racemic mixtures and thus significantly increase the efficiency of complex synthetic pathways. Based on reports that lipases, which today are already particularly important tools in chemical synthesis, can catalyze the enantiospecific turnover of trimethylsilanol (TMS)‐protected alcohols, the goal of this study was to determine the conditions under which such a catalysis occurs. Through detailed experimental and mechanistic investigation, we demonstrated that although lipases mediate the turnover of TMS‐protected alcohols, this occurs independently of the known catalytic triad, as this is unable to stabilize a tetrahedral intermediate. The reaction is essentially non‐specific and therefore most likely completely independent of the active site. This rules out lipases as catalysts for the resolution of racemic mixtures of alcohols through protection or deprotection with silyl groups.

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Section: Resultsmentioning

confidence: 98%

“…[17] It is found in literature that high concentrations of BSA decrease the buffering capacity of blood. [18] Possibly, this indicates that protein acidity favors the hydrolysis of TMS-PhE.…”

Section: Hydrolysis Of Tms-protected 1-phenylethanolmentioning

confidence: 99%

Lipase‐Mediated Conversion of Protecting Group Silyl Ethers: An Unspecific Side Reaction

Pick,

Wenzlaff,

Yousefi

et al. 2023

ChemBioChem

View full text Add to dashboard Cite

show abstract

“…In critically ill patients, hypoalbuminemia is primarily caused by fluid overload, endothelial leak, and nutritional deficiencies [ 41 ]. While it may appear that alkalosis resulting from hypoalbuminemia could prevent the development of acidosis, this notion is inaccurate [ 42 ]. As a compensatory mechanism, the decrease in ATOT and the increase in pH prompt the retention of chloride, which subsequently decreases the SID.…”

Section: The Biochemical Basis Of Fluid Use In the Surgical Settingmentioning

confidence: 99%

Role of Crystalloids in the Perioperative Setting: From Basics to Clinical Applications and Enhanced Recovery Protocols

Lorente,

Hahn,

Jover

et al. 2023

JCM

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Perioperative fluid management, a critical aspect of major surgeries, is characterized by pronounced stress responses, altered capillary permeability, and significant fluid shifts. Recognized as a cornerstone of enhanced recovery protocols, effective perioperative fluid management is crucial for optimizing patient recovery and preventing postoperative complications, especially in high-risk patients. The scientific literature has extensively investigated various fluid infusion regimens, but recent publications indicate that not only the volume but also the type of fluid infused significantly influences surgical outcomes. Adequate fluid therapy prescription requires a thorough understanding of the physiological and biochemical principles that govern the body’s internal environment and the potential perioperative alterations that may arise. Recently published clinical trials have questioned the safety of synthetic colloids, widely used in the surgical field. A new clinical scenario has arisen in which crystalloids could play a pivotal role in perioperative fluid therapy. This review aims to offer evidence-based clinical principles for prescribing fluid therapy tailored to the patient’s physiology during the perioperative period. The approach combines these principles with current recommendations for enhanced recovery programs for surgical patients, grounded in physiological and biochemical principles.

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“…Most proteins in the body act as buffers. Proteins are composed of amino acids that contain positively charged amino groups and negatively charged carboxyl groups, and can act as buffers by combining with hydrogen and hydroxide ions [ 28 , 29 ]. The buffer system of the human body is highly effective and can adjust pH within seconds.…”

Section: Introductionmentioning

confidence: 99%

Targeted hyperalkalization with NaOH-loaded starch implants enhances doxorubicin efficacy in tumor treatment

Lee

2023

Asian Journal of Pharmaceutical Sciences

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On acid-base effects of albumin

Cited by 14 publications

References 3 publications

Lipase‐Mediated Conversion of Protecting Group Silyl Ethers: An Unspecific Side Reaction

Lipase‐Mediated Conversion of Protecting Group Silyl Ethers: An Unspecific Side Reaction

Role of Crystalloids in the Perioperative Setting: From Basics to Clinical Applications and Enhanced Recovery Protocols

Targeted hyperalkalization with NaOH-loaded starch implants enhances doxorubicin efficacy in tumor treatment

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