On Allosteric Models

Wyman, Jeffries

doi:10.1007/978-94-010-2579-9_14

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…It is interesting to regard the circulating blood, with its many control ligands, as an imperfect Carnot engine, i.e. one operating under partially reversible conditions (Wyman, 1972). The same is true of the active transport of a component across a membrane by a carrier molecule (facilitated diffusion).…”

Section: T H E Macromolecule As a Carnot Enginementioning

confidence: 99%

Linkage graphs: a study in the thermodynamics of macromolecules

Wyman

1984

Quart. Rev. Biophys.

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In earlier papers (Wyman, 1975a, b, 1981) I have called attention to the existence of a group of linkage potentials derivable from one another by a corresponding group of Legendre transformations. These potentials are applicable to any system in a state of equilibrium but are especially useful in the study of the behaviour, or, as we may say, the functional chemistry, of a macromolecule in the presence of its ligands. In this paper I show how these potentials may be represented by a set of contour graphs which embody the results of observation and are transformable into one another by a group of graphical permutations equivalent to the Legendre group.

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Section: T H E Macromolecule As a Carnot Enginementioning

confidence: 99%

Linkage graphs: a study in the thermodynamics of macromolecules

Wyman

1984

Quart. Rev. Biophys.

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Kinetik und Regulation des Stoffwechsels

Jungermann

Möhler

1980

Übungen Und Prüfungsfragen Biochemie

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Nested allosteric interaction in tarantula hemocyanin revealed through the binding of oxygen and carbon monoxide

Decker

Connelly²,

Robert³

et al. 1988

Biochemistry

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We have examined the competitive binding of oxygen and carbon monoxide to the multisubunit hemocyanin of the tarantula Eurypelma californicum. Employment of high-precision thin-layer methods has enabled detailed characterization of the pure oxygen and pure carbon monoxide binding curves, as well as binding curves performed under mixed-gas conditions. The pure oxygen binding curve and the displacement of oxygen by carbon monoxide at full ligand saturation are highly cooperative, but in the absence of oxygen, carbon monoxide binds noncooperatively. The results were analyzed globally within the framework of a nested allosteric model [Robert, C.H., Decker, H., Richey, B., Gill, S.J., & Wyman, J. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 1891-1895] which takes into account the hierarchy of subunit structure present in the macromolecule. The use of two ligands enables one to recognize two distinct levels of allosteric interaction functioning in the protein assembly. The binding characteristics of the allosteric states demonstrated for Eurypelma follow a similar pattern as those found earlier for Homarus americanus.

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On Allosteric Models

Cited by 3 publications

References 9 publications

Linkage graphs: a study in the thermodynamics of macromolecules

Linkage graphs: a study in the thermodynamics of macromolecules

Kinetik und Regulation des Stoffwechsels

Nested allosteric interaction in tarantula hemocyanin revealed through the binding of oxygen and carbon monoxide

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