On Amino-acids

Dakin, H.D.

doi:10.1042/bj0120290

Cited by 161 publications

(27 citation statements)

References 2 publications

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“…Treatment of 4-(ω-chloroalkanoyl)-1-arylpiperazines 4 with hydantoins 3, 30,31 in the presence of NaH and N,N-dimethylformamide (DMF), gave the corresponding intermediates 5 (in 60-70% yield), which were reduced by LiAlH 4 in THF to provide the desired compounds 2a-j (in 40-67% yield). This sequence is particularly useful for preparing compounds 2, since the direct reduction of 1 29 (obtained in 20-50% yield) proceeds with low overall yields.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT_1AAffinity/Selectivity

et al. 1997

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A series of new arylpiperazine derivatives 2, which are devoid of the terminal amide fragment present in related 5-HT1A ligands, was prepared and evaluated for affinity at 5-HT1A and alpha 1 receptors. All the compounds 2 demonstrated high affinity for the 5-HT1A receptor and moderate affinity for alpha 1 receptor binding sites. Structure-activity relationship (SAR) studies suggest that there is influence of electronic factors on the no-pharmacophoric part of the alpha 1 receptor site. However there is no influence of electronic interactions on the stabilization of the 5-HT1A receptor-ligand complex.

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Section: Chemistrymentioning

confidence: 99%

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT_1AAffinity/Selectivity

et al. 1997

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“…of extracting protein hydrolysates, the yields of dicarboxylic amino acids isolated from casein have been increased from 16.9 to 36.4 per cent (2). In short, the yield of these divalent acids has been more than doubled.…”

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confidence: 76%

Studies in the Physical Chemistry of the Proteins

Cohn

Berggren

Hendry

1924

Journal of General Physiology

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It has not often been possible to consider the relation between the composition of proteins and their behavior. This has been due, in part, to the complexity of this class of substances; a complexity often as bewildering as the organizations and symmetries of the biological systems which proteins constitute, and always more intricate than the stereochemistry of the simpler organic compounds of which proteins are, in turn, composed. The large molecular weights of the proteins, and the large number of amino acids that combine with each other to produce these vast molecules give abundant evidence of their structural complexity. The failure to correlate the behavior of proteins with their composition has probably depended less upon this complexity, however, than upon incomplete knowledge of the amino acids they contain.Recent advances in the methods of isolating and of estimating amino acids have greatly increased our knowledge of the composition of certain proteins. Thus the composition of casein is now 94.2 per cent 1 known (1). As a result of Dakin's new butyl alcohol method 1 The convention has been followed of referring to the ratio of the weight of the amino acid recovered, to the weight of the protein analyzed as the percentage composition of the protein. The water absorbed by the amino acids during hydrolysis should, of course, be added to the denominator, in order to yield the true percentage composition.

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“…(4) Due, presumably, to the presence of several types of functional groups, even after purification the substance has failed to crystallize. In this respect it appears to behave somewhat like p-hydroxy-glutamic acid, which, according to Dakin (1918), makes up ro./d of casein, yet is not available on the market at any price. ( 5 ) Pantothenic acid is itself unstable and can be handled safely only as a neutral salt.…”

Section: T H I S Was Obtained In (+)mentioning

confidence: 99%

Growth‐promoting Nutrilites for Yeasts

Williams

1941

Biological Reviews

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On Amino-acids

Cited by 161 publications

References 2 publications

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT_1AAffinity/Selectivity

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT_1AAffinity/Selectivity

Studies in the Physical Chemistry of the Proteins

Growth‐promoting Nutrilites for Yeasts

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On Amino-acids

Cited by 161 publications

References 2 publications

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT1AAffinity/Selectivity

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT1AAffinity/Selectivity

Studies in the Physical Chemistry of the Proteins

Growth‐promoting Nutrilites for Yeasts

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Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT_1AAffinity/Selectivity

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT_1AAffinity/Selectivity