ON and OFF inhibition as mechanisms for forward masking in the inferior colliculus: a modeling study

Gai, Yan

doi:10.1152/jn.00892.2015

Cited by 14 publications

(21 citation statements)

References 89 publications

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“…In a recent study Nelson et al (2009) recorded neuronal activity from the central nucleus the inferior colliculus of awake marmosets, and concluded that forward masking could be better explained in terms of inhibitory mechanisms either in the IC or at lower sites of the auditory pathways. A possible interpretation is that the inferior colliculus might receive inhibitory inputs from the superior paraolivary nucleus (SPON), that would result in a wide dynamic range inhibitory mechanism locked to sound offset (Gai 2016). However, the large variability in forward masking in their dataset makes difficult to reconcile their neuronal threshold shifts with psychophysical threshold shifts.…”

Section: Discussionmentioning

confidence: 99%

“…Inhibition/suppression, neuronal adaptation, inhibition or forward suppression, and offset inhibition are all mechanisms that have been proposed to contribute to simultaneous and non-simultaneous masking (e.g. Duifhuis, 1973; Nelson and Swain, 1996; Oxenham and Moore 1995, 1997; Harris and Dallos, 1979; Brosch and Schreiner, 1997; Gai 2016). …”

Section: Introductionmentioning

confidence: 99%

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Spatial and temporal disparity in signals and maskers affects signal detection in non-human primates

et al. 2017

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Detection thresholds for auditory stimuli (signals) increase in the presence of maskers. Natural environments contain maskers/distractors that can have a wide range of spatiotemporal properties relative to the signal. While these parameters have been well explored psychophysically in humans, they have not been well explored in animal models, and their neuronal underpinnings are not well understood. As a precursor to the neuronal measurements, we report the effects of systematically varying the spatial and temporal relationship between signals and noise in macaque monkeys (Macaca mulatta and Macaca radiata). Macaques detected tones masked by noise in a Go/No-Go task in which the spatiotemporal relationships between the tone and noise were systematically varied. Masked thresholds were higher when the masker was continuous or gated on and off simultaneously with the signal, and lower when the continuous masker was turned off during the signal. A burst of noise caused higher masked thresholds if it completely temporally overlapped with the signal, whereas partial overlap resulted in lower thresholds. Noise durations needed to be at least 100 ms before significant masking could be observed. Thresholds for short duration tones were significantly higher when the onsets of signal and masker coincided compared to when the signal was presented during the steady state portion of the noise (overshoot). When signal and masker were separated in space, masked signal detection thresholds decreased relative to when the masker and signal were co-located (spatial release from masking). Masking release was larger for azimuthal separations than for elevation separations. These results in macaques are similar to those observed in humans, suggesting that the specific spatiotemporal relationship between signal and masker determine threshold in natural environments for macaques in a manner similar to humans. These results form the basis for future investigations of neuronal correlates and mechanisms of masking.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spatial and temporal disparity in signals and maskers affects signal detection in non-human primates

et al. 2017

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“…In a recent modeling study of SPON neurons, an ON and OFF inhibition was proposed as a potential mechanism of forward masking (Gai 2016) (note that Gai (2016) used frozen noise as the masker, in contrast to the physiological study conducted by Nelson et al (2009) and the current study, in which the masker was a pure tone at CF). In the Gai study, offset responses of the model SPON (OFF inhibition) were combined with delayed during-stimulus responses of the model DNLL (ON inhibition) to account for observed suppression at the level of the IC.…”

Section: Duration Of Spon Offset Responsementioning

confidence: 81%

“…Inhibition would play an important role in the rate suppression caused by the masker in IC neurons (Nelson et al 2009;Gai 2016). In order to investigate the inhibitory effect of the SPON neuron on the forward-masking paradigm at the level of IC, a model of an IC neuron with a low-pass/band reject rate MTF and a sustained response to pure tones was used as the target of our SPON model responses.…”

Section: Forward Masking In the Icmentioning

confidence: 99%

Modeling Responses in the Superior Paraolivary Nucleus: Implications for Forward Masking in the Inferior Colliculus

Salimi

Zilany

Carney

2017

JARO

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A phenomenological model of the responses of neurons in the superior paraolivary nucleus (SPON) of the rodent is presented in this study. Pure tones at the characteristic frequency (CF) and broadband noise stimuli evoke offset-type responses in these neurons. SPON neurons also phase-lock to the envelope of sinusoidally amplitude-modulated (SAM) stimuli for a range of modulation frequencies. Model SPON neuron received inhibitory input that was relayed by the ipsilateral medial nucleus of the trapezoid body from the contralateral model ventral cochlear nucleus neuron. The SPON model response was simulated by detecting the slope of its inhibitory postsynaptic potential. Responses of the proposed model to pure tones at CF and broadband noise were offset-type independent of the duration of the input stimulus. SPON model responses were also synchronized to the envelope of SAM stimuli with precise timing for a range of modulation frequencies. Modulation transfer functions (MTFs) obtained from the model response to SAM stimuli resemble the physiological MTFs. The output of the proposed SPON model provides an input for models of physiological responses at higher levels of the ascending auditory pathway and can also be utilized to infer possible mechanisms underlying gap detection and duration encoding as well as forward masking at the level of the auditory midbrain.

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“…The response of a neuron or a neural circuit to a sustained stimulus can bear three basic features: a response to the stimulus onset (On response), a sustained response as long the stimulus is present, and a response to the stimulus offset (Off response). The On/Off responses are found in neurons of the superior paraolivary nucleus (SPON) of the brainstem, the inferior colliculus (IC) of the midbrain [22], and the auditory cortex [80,4,20]. These On/Off neurons are thought to support functions such as duration selectivity (duration tuning), gap detection, and noise rejection [106].…”

Section: Introductionmentioning

confidence: 99%

A generic deviance detection principle for cortical On/Off responses, omission response, and mismatch negativity

Chien¹,

Maess

Knösche

2019

Preprint

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ON and OFF inhibition as mechanisms for forward masking in the inferior colliculus: a modeling study

Abstract: Gai Y. ON and OFF inhibition as mechanisms for forward masking in the inferior colliculus: a modeling study.

Cited by 14 publications

References 89 publications

Spatial and temporal disparity in signals and maskers affects signal detection in non-human primates

Spatial and temporal disparity in signals and maskers affects signal detection in non-human primates

Modeling Responses in the Superior Paraolivary Nucleus: Implications for Forward Masking in the Inferior Colliculus

A generic deviance detection principle for cortical On/Off responses, omission response, and mismatch negativity

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