On Antimutagenesis Mechanism in Plants

Serebryanyi, A. M.; Zoz, N. N.; Morozova, I. S.

doi:10.1007/s11177-005-0124-7

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“…It is believed that effectiveness of radioprotective substances after cell irradiation could be caused by activation of DNA repair or other irradiation recovery processes, in particular stimulation of repopulation [19]. Repopulation as a reaction of organisms to irradiation exposure was studied in detail in many model systems, including its stimulation by antimutagens [19][20][21]. Well-known adaptogenic properties of humates suppose their impact also on other processes of post-radiation recovery [1][2][3][4].…”

Section: Resultsmentioning

confidence: 99%

Radioprotective Properties of Sodium Humate in Radiation-Induced Mutagenesis in Cultured Lymphocytes of Thyroid Cancer Patients

Shkarupa

2016

Exp. Onc.

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Aim: To investigate the effect of sodium humate on the level of cytogenetic damage in culture of lymphocytes of patients with thyroid cancer after γ-irradiation. Materials and Methods: Metaphase analysis of chromosome aberrations in cultured peripheral blood lymphocytes of 10 individuals with thyroid cancer was performed after irradiation of lymphocytes in vitro at a dose of 1 Gy from 137Cs source at the early G0 phase of cell cycle. Sodium humate was added to cell culture for 30 ± 15 min after phytohemagglutinin stimulation at concentrations of 10 and 100 μg/ml. Results: Sodium humate exhibited antimutagenic properties. The preparation at a concentration of 10 μg/ml was more effective than at a concentration of 100 μg/ml, reducing the average incidence of radiation-induced chromosome aberrations by 51.88 and 38.77%, respectively. The most pronounced antimutagenic effect of sodium humate was the reduction of the frequency of chromosomal type aberrations, however, such efficiency varied between individual patients with thyroid cancer. Conclusions: Sodium humate could be considered as a potential therapeutic modifier of radiation damage.

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Section: Resultsmentioning

confidence: 99%

Radioprotective Properties of Sodium Humate in Radiation-Induced Mutagenesis in Cultured Lymphocytes of Thyroid Cancer Patients

Shkarupa

2016

Exp. Onc.

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show abstract

On Antimutagenesis Mechanism in Plants

Cited by 1 publication

References 2 publications

Radioprotective Properties of Sodium Humate in Radiation-Induced Mutagenesis in Cultured Lymphocytes of Thyroid Cancer Patients

Radioprotective Properties of Sodium Humate in Radiation-Induced Mutagenesis in Cultured Lymphocytes of Thyroid Cancer Patients

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