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Purpose:To optimize diffusion-relaxation MRI with tensor-valued diffusion encoding for precise estimation of compartment-specific fractions, diffusivities, and T 2 values within a two-compartment model of white matter, and to explore the approach in vivo. Methods: Sampling protocols featuring different b-values (b), b-tensor shapes (b Δ ), and echo times (TE) were optimized using Cramér-Rao lower bounds (CRLB).Whole-brain data were acquired in children, adults, and elderly with white matter lesions. Compartment fractions, diffusivities, and T 2 values were estimated in a model featuring two microstructural compartments represented by a "stick" and a "zeppelin." Results: Precise parameter estimates were enabled by sampling protocols featuring seven or more "shells" with unique b/b Δ /TE-combinations. Acquisition times were approximately 15 minutes. In white matter of adults, the "stick" compartment had a fraction of approximately 0.5 and, compared with the "zeppelin" compartment, featured lower isotropic diffusivities (0.6 vs. 1.3 μm 2 /ms) but higher T 2 values (85 vs. 65 ms). Children featured lower "stick" fractions (0.4). White matter lesions exhibited high "zeppelin" isotropic diffusivities (1.7 μm 2 /ms) and T 2 values (150 ms). Conclusions: Diffusion-relaxation MRI with tensor-valued diffusion encoding expands the set of microstructure parameters that can be precisely estimated and therefore increases their specificity to biological quantities.
K E Y W O R D Sbrain microstructure, diffusion-relaxation MRI, Fisher information, tensor-valued diffusion encoding 1606 | LAMPINEN Et AL. S (u) = (K ⊛ P) (u) = ∫ |n|=1 K(u ⋅ n) P(n) dn,(2) K(u ⋅ n) = S 0 J