2006
DOI: 10.1039/b517670k
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On-chip extrusion of lipid vesicles and tubes through microsized apertures

Abstract: In this work we present the formation of micrometre-sized lipid vesicles and tubes with perfectly homogeneous diameter and extraordinary length. The method is a novel approach for unconventional fabrication of soft-matter microstructured devices based on the combination of top-down and bottom-up fabrication processes. Photolithography techniques are applied to fabricate microsized apertures that provide the requirements to form lipid structures with predictable size and to align and guide the vesicles and tube… Show more

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Cited by 60 publications
(53 citation statements)
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“…2004). We note that the tight twists of the tubes (figure 1, top left inset) are a more extreme property of very narrow tubes of proteolipid, but this phenomenon can also be induced when lipid is extruded from nanoholes, and there, rather than twisting like a rope, it coils into helices (Dittrich et al . 2006).…”
Section: Discussionmentioning
confidence: 99%
“…2004). We note that the tight twists of the tubes (figure 1, top left inset) are a more extreme property of very narrow tubes of proteolipid, but this phenomenon can also be induced when lipid is extruded from nanoholes, and there, rather than twisting like a rope, it coils into helices (Dittrich et al . 2006).…”
Section: Discussionmentioning
confidence: 99%
“…In particular, the formation of crystals and nanoparticles was achieved in microchannels in superior quality due to the excellent handling of small fluid volumes of nano‐ and even picolitres 6, 7. Several studies report the formation of polymer fibers, metal wires, and tubular structures in simple planar microfluidic networks 8–10. One important difference of microfluidic systems compared to conventional large‐scale manufacturing processes is the reproducible, well‐controlled supply of reagents due to the laminar flow regime present in microfluidic channels.…”
mentioning
confidence: 99%
“…The formed tubes at different stages are shown in Figure 1b. Dittrich et al 15 applied photolithography techniques to fabricate micro-sized apertures that provide a way to form lipid structures with predictable sizes. When a vacuum pump was connected to the outlet, lipid tubes with a perfectly homogeneous diameter and extraordinary length were generated.…”
Section: Microfluidic Ways To Form Lipid Tubesmentioning
confidence: 99%