“…Microfluidics has achieved great progress recently due to its own excellent performance in fluidic handling [ 7 , 8 , 9 ], micro-environment control [ 10 , 11 , 12 ] and signal amplification [ 13 , 14 ]. By integrating advanced micro- and nano-optical systems with well-developed microfluidics technology, optofluidics has ushered in a new era of lab-on-a-chip functionality [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ], including biochemical sensing with optical measurement [ 23 ], optofluidic imaging [ 24 ], and light-driven manipulation [ 25 , 26 ]. In the case of RI sensing, many valuable review papers such as Fan’s [ 27 ] have found that synergistic integration creates unique characteristics that promote the performance and function of biological/chemical analysis.…”