2024
DOI: 10.1088/1758-5090/ad80ce
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On-chip human lymph node stromal network for evaluating dendritic cell and T-cell trafficking

Brian J Kwee,
Mona Mansouri,
Adovi Akue
et al.

Abstract: The lymph node paracortex, also known as the T-cell zone, consists of a network of fibroblastic reticular cells (FRCs) that secrete chemokines to induce T-cell and dendritic cell trafficking into the paracortex. To model the lymph node paracortex, we utilize multi-channel microfluidic devices to engineer a 3D lymph node stromal network from human cultured FRCs embedded in a collagen I-fibrin hydrogel. In the hydrogel, the FRCs self-assemble into an interconnected network, secrete the extracellular matrix prote… Show more

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