On-chip micromanipulation using a magnetically driven micromanipulator with an acoustically oscillating bubble

Park, Il Song; Shin, Jae Ho; Lee, Young Rang; Chung, Sang Kug

doi:10.1016/j.sna.2016.08.001

Cited by 17 publications

(9 citation statements)

References 44 publications

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“…61,62 These fluid flows can additionally trap objects, and then the system can be carried by a magnetic transporter. 63,64 Microrobot teams and swarms remain a critical research topic, because such an organization paves the way of parallel and distributed complex operations. 65 Swarm control is of particular importance as commands might be given to the whole population, subsets, individuals, or a combination of these.…”

Section: Off-board Approaches For Microrobotsmentioning

confidence: 99%

Mobile microrobots for bioengineering applications

et al. 2017

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Untethered micron-scale mobile robots can navigate and non-invasively perform specific tasks inside unprecedented and hard-to-reach inner human body sites and inside enclosed organ-on-a-chip microfluidic devices with live cells. They are aimed to operate robustly and safely in complex physiological environments where they will have a transforming impact in bioengineering and healthcare. Research along this line has already demonstrated significant progress, increasing attention, and high promise over the past several years. The first-generation microrobots, which could deliver therapeutics and other cargo to targeted specific body sites, have just been started to be tested inside small animals toward clinical use. Here, we review frontline advances in design, fabrication, and testing of untethered mobile microrobots for bioengineering applications. We convey the most impactful and recent strategies in actuation, mobility, sensing, and other functional capabilities of mobile microrobots, and discuss their potential advantages and drawbacks to operate inside complex, enclosed and physiologically relevant environments. We lastly draw an outlook to provide directions in the veins of more sophisticated designs and applications, considering biodegradability, immunogenicity, mobility, sensing, and possible medical interventions in complex microenvironments.

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Section: Off-board Approaches For Microrobotsmentioning

confidence: 99%

Mobile microrobots for bioengineering applications

et al. 2017

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“…where V b is the volume of the particle, m is the magnetic permeability of the particle and m 0 is the magnetic permeability of the free space. By substituting equation (6) into equation (5), the magnetic force can be obtained as…”

Section: Equations Of Motion For Magnetic Microparticlesmentioning

confidence: 99%

“…Manipulation of the magnetic microparticles has been drawing great attention in recent years due to wide range of applications in biology and medicine. [1][2][3][4][5][6][7] The most commonly used microparticles are made from superparamagnetic or ferromagnetic core materials. These particles are commercially available in sizes ranging from 0.2 to 100 mm and are conjugated with specific antibodies or chemicals to make them functional for various applications.…”

Section: Introductionmentioning

confidence: 99%

Feedback controller designs for an electromagnetic micromanipulator

Böyük

Eroğlu

Ablay

et al. 2019

Proceedings of the Institution of Mechanical Engineers, Part I:

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Magnetic micromanipulators are capable of generating wide range of magnetic forces to manipulate magnetic microparticles for biomedical applications. In this study, a multipole magnetic micromanipulator system including electromagnets, driver circuitry and control unit is designed, modeled and implemented. The micromanipulator can produce a broad range of magnetic forces up to 25 pN on a single magnetic microparticle (1–10 µm diameter) that is 5 mm away from the electromagnet core tip. Both linear and nonlinear controllers are designed and implemented, and the proposed nonlinear controller produces smooth control currents to assure closed-loop stability of the system with 1 s non-overshoot transient response and zero steady-state tracking error. The maximum output current of the driver circuitry is set to 1 A. The single particle at the center is moved at a speed of 5 mm/s. The fully automatic system can be utilized in applications related to single cell or microparticle manipulations.

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“…22 It is found that this force is strong enough to hold the micro-objects when the bubble is being transported. 23 The technique based on oscillating bubbles can carry, transfer, and manipulate micro-objects without direct contact.…”

Section: Introductionmentioning

confidence: 99%

Manipulation of micro-objects using acoustically oscillating bubbles based on the gas permeability of PDMS

Liu

Tian

et al. 2018

Biomicrofluidics

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This paper presents a novel manipulation method for micro-objects using acoustically oscillating bubbles with a controllable position based on the gas permeability of polydimethylsiloxane. The oscillating bubble trapped within the side channel attracts the neighboring micro-objects, and the position of the air-liquid interface is controlled by generating temporary pressure difference between the side channel and the air channel. To demonstrate the feasibility of the method in technological applications, polystyrene microparticles of 10 m in diameter were successfully captured, transported, and released. The influence of pressure difference on the movement speed of the air-liquid interface was demonstrated in our experiments, and the manipulation performance was also characterized by varying the frequency of the acoustic excitation and the pressure difference. Since the bubble generation and the air-liquid interface movement in our manipulation method do not need any electrochemical reaction and any high temperature, this on-chip manipulation method provides a controllable, efficient, and noninvasive tool for handling micro-objects such as particles, cells, and other entities. The whole manipulation process, including capturing, transporting, and releasing of particles, spent less than 1 min. It can be used to select the cells and particles in the microfluidic device or change the cell culture medium.

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On-chip micromanipulation using a magnetically driven micromanipulator with an acoustically oscillating bubble

Cited by 17 publications

References 44 publications

Mobile microrobots for bioengineering applications

Mobile microrobots for bioengineering applications

Feedback controller designs for an electromagnetic micromanipulator

Manipulation of micro-objects using acoustically oscillating bubbles based on the gas permeability of PDMS

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