On-chip phase measurement for microparticles trapped on a waveguide

Dullo, Firehun Tsige; Hellesø, Olav Gaute

doi:10.1039/c5lc00794a

Cited by 8 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chip-based platform also supports different on-chip optical modalities such as Raman spectroscopy on chip [22], on-chip micro-particle manipulation [23], interferometric microparticle sensing [24] and gas sensing [25], where several of these techniques can be combined creating advanced lab-on-a-chip multimodality platforms. In this work, we have investigated the relationship between waveguide widths and some parameters related to extending the FOV in super-resolution microscopy imaging.…”

Section: Discussionmentioning

confidence: 99%

Nanoscopy on-a-chip: super-resolution imaging on the millimeter scale

Helle¹,

Coucheron²,

Tinguely³

et al. 2019

Opt. Express

View full text Add to dashboard Cite

Optical nanoscopy techniques can image intracellular structures with high specificity at sub-diffraction limited resolution, bridging the resolution gap between optical microscopy and electron microscopy. So far conventional nanoscopy lacks the ability to generate high throughput data, as the imaged region is small. Photonic chip-based nanoscopy has demonstrated the potential for imaging large areas, but at a lateral resolution of 130 nm. However, all the existing super-resolution methods provide a resolution of 100 nm or better. In this work, chip-based nanoscopy is demonstrated with a resolution of 75 nm over an extraordinarily large area of 0.5 mm x 0.5 mm, using a low magnification and high N.A. objective l ens. Furthermore, the performance of chip-based nanoscopy is benchmarked by studying the localization precision and illumination homogeneity for different waveguide widths. The advent of large field-of-view chip-based nanoscopy opens up new routes in diagnostics where high throughput is needed for the detection of non-diffuse disease, or rare events such as the early detection of cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Nanoscopy on-a-chip: super-resolution imaging on the millimeter scale

Helle¹,

Coucheron²,

Tinguely³

et al. 2019

Opt. Express

View full text Add to dashboard Cite

show abstract

Near‐Field Optical Tweezers for Chemistry and Biology

Liao

Cai

et al. 2019

Physica Status Solidi (a)

View full text Add to dashboard Cite

Near‐field optical tweezer techniques have been essential for the development for manipulation and identification of micro‐ and nanoparticles (NPs) in lab‐on‐a‐chip systems. Optical waveguide, which has been exploited as a fascinating manipulation approach, provides valuable insights into the biology of the specific type of cells and potential for enhanced Raman spectroscopy. Specific waveguides and its own structures in near‐field optical techniques can be used to trap, transport, sort, levitate, and deform a micro‐ or NP in colloid chemistry and pharmaceutical biology. Given the precise manipulation and trapping stiffness with low light power, a diverse range of micro/nanostructured optical fiber, silicon‐on‐insulator resonator, photonic crystal cavity, and plasmonic waveguide have been proposed in many theoretical models and experimental observations, including polystyrene bead, silica bead, metal particle, erythrocyte, virus, and DNA. Considering the optical pressure fundamental, fabrication process, and structure categorization, this review describes recent mainstream developments and future perspectives of near‐field optical tweezers for chemical and biological applications.

show abstract

Near‐Field Optical Tweezers for Chemistry and Biology

Liao

Cai

et al. 2020

Physica Status Solidi (a)

View full text Add to dashboard Cite

On-chip phase measurement for microparticles trapped on a waveguide

Cited by 8 publications

References 25 publications

Nanoscopy on-a-chip: super-resolution imaging on the millimeter scale

Nanoscopy on-a-chip: super-resolution imaging on the millimeter scale

Near‐Field Optical Tweezers for Chemistry and Biology

Near‐Field Optical Tweezers for Chemistry and Biology

Contact Info

Product

Resources

About