On-chip plasmonic detection of microRNA-106a in gastric cancer using hybridized gold nanoparticles

Park, Sang Heon; Lee, Jihye; Yeo, Jong‐Souk

doi:10.1016/j.snb.2018.02.010

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…The bonding dimer plasmon (BDP) mode in this regime shows a red-shifting of the plasmon peak wavelength from a single particle; this is attributable to its near-field coupling with an enhanced near-field, which provides a useful fingerprint of the plasmonic cavity. [68][69][70][71][72] Within this range, the local Drude model for the dielectric function is generally acceptable for describing the light-matter interactions as spatially localized responses. For plasmon coupling with a sub-nanometer gap, the quantum nature of the electron alters the plasmonic response.…”

Section: Classical and Quantum Nanoplasmonics: From Bulk Nano And Cluster Scales Down To Atomic Mattermentioning

confidence: 99%

Quantum Plasmonics: Energy Transport Through Plasmonic Gap

2021

Self Cite

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scanning tunneling microscopy (STM), [5,6] atomic force microscopy (AFM), [7] and other techniques allowing resolution to be reduced to the atomic scale can help realize atomic-scale world exploration. This is the starting point of the nanotechnology era; since its inception, this technology has changed the nature of almost every human-made object. Six decades after Richard Feynman's lecture, we find that there is still plenty of room at the bottom, through the incorporation of nanophotonics. [8] To elucidate: quantum plasmonics has emerged as an attractive research field in new nanophotonics; research is underway to reveal and accurately describe the quantum nature of electrons at the bottom of extremely confined nano-or sub-nanometer scale materials, using light. [9,10] By exploring the quantum mechanical interactions of matter with light (in particular, using the coherent interactions between the plasmonic cavity and the material), [11][12][13][14][15][16][17][18] these efforts seek to establish new frontiers in information processing technology and to satisfy the everincreasing requirements for speed and capacity in quantum computing, quantum cryptography, and quantum metrology. They might also suggest research fields beyond this, involving the ultimate miniaturization of photonic components and the extreme limits of the light-matter interaction. These advantages may help solve some fundamental problems of electronics, such as those of bandwidth, frequency, and energy consumption. [19] In this review, we describe recent developments in the research of exotic materials capable of mediating quantum plasmonics and inducing quantum energy transport. We briefly provide classical and quantum descriptions of matter, from the bulk, nano, and cluster scales down to atomic matter, exploring the band structures via their optical responses. By considering a single nanoplasmonic material, we describe the theoretical and experimental findings pertaining to assembled nanoplasmonic structures, in the context of the plasmonic gap distance and the type of advanced functional material. The plasmonic gap herein refers to a nanometer or sub-nanometer gap that transports (couples, tunnels, exchanges, confines) electromagnetic energy between plasmonic resonators. Advanced functional materials within an extremely confined metallic resonator are described; these include air/vacuum, aliphatic and conjugated molecules, 2D materials, organic and inorganic materials with At the interfaces of metal and dielectric materials, strong light-matter interactions excite surface plasmons; this allows electromagnetic field confinement and enhancement on the sub-wavelength scale. Such phenomena have attracted considerable interest in the field of exotic material-based nanophotonic research, with potential applications including nonlinear spectroscopies, information processing, single-molecule sensing, organic-molecule devices, and plasmon chemistry. These innovative plasmonics-based technologies can meet the ever-increasing demands for speed and ca...

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Section: Classical and Quantum Nanoplasmonics: From Bulk Nano And Cluster Scales Down To Atomic Mattermentioning

confidence: 99%

Quantum Plasmonics: Energy Transport Through Plasmonic Gap

2021

Self Cite

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“…Moreover, the LOD was estimated as approximately 1.9 nM by 3 signal-tonoise ratio (20 times determination of the blank solution). This method exhibited a lower LOD than other recently reported assays [19,23]. Additionally, as the concentration of miRNAs in plasma is up to ∼nM, the change of the SPR absorption peak absorbance can be meaningful for clinical application.…”

Section: Rna Hybridization Assay For the Detection Of Mirna-148amentioning

confidence: 78%

“…For the detection of miRNAs, a variety of approaches have been studied such as electrical, mass, and optical sensors with the aid of micro-electro-mechanical systems as well as nanotechnology [16][17][18][19]. More traditional and widely used methods such as polymerase chain reaction (PCR) can measure promising biomarker miRNAs but still have many limitations and relatively low sensitivity [20].…”

Section: Introductionmentioning

confidence: 99%

A colorimetric detection of microRNA-148a in gastric cancer by gold nanoparticle–RNA conjugates

et al. 2019

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For the early diagnosis of gastric cancer, microRNA-148a (miRNA-148a) as a promising biomarker is measured by a simple colorimetric biosensor due to its unique surface plasmon resonance (SPR) absorption of gold nanoparticles (AuNPs). In the assay system, the sensing probes are facilitated by the conjugation of AuNPs with RNA probes (RNAP) via Au–S bonds, which align in a tail-to-tail fashion onto the target RNA. When miRNA-148a is introduced, a sandwich hybridization reaction is triggered between the AuNP–RNAP conjugates and targets, resulting in changes in the SPR absorption band, microscopic distribution and macroscopic color of the AuNP solution. Following this principle, this colorimetric method is able to quantitatively detect miRNA-148a at nanomolar level with a limit of ∼1.9 nM, and exhibits high sensitivity and selectivity by a low-cost UV–vis spectrometer or even the naked eye. Moreover, the AuNP network materials with a characteristic sharp ‘melting transition’ provide significant guidance for the reusability of DNA or RNA biosensors.

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“…The combination of PTh and rGO layers on the SPCE surface aimed to enhance the conductivity and stability of the electrode, which was vital for improving the performance of the biosensing platform. In the same year, Park et al, introduced on-chip colorimetric biosensing for the early detection of the same biomarker [86]. The platform was based on the plasmon coupling of hybridized AuNPs showing high specificity and sensitivity.…”

Section: Rna Nanobiosensors In Gcmentioning

confidence: 99%

Can Nano Yield Big Insights? Oligonucleotide-Based Biosensors in Early Diagnosis of Gastric Cancer

Avanu,

Ciubotariu,

Dodi

2024

Chemosensors

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Gastric cancer (GC) remains a significant global health challenge, with late-stage diagnosis impacting treatment options and decreased survival rates. To address this, there has been a growing interest in the development of innovative screening and diagnostic methods. Over the past 20 years, nanobiosensors have undergone multiple iterations and unveiled remarkable features that pledge to reshape patient care. Despite the excitement over the plethora of ground-breaking advancements for cancer detection, use-ready samples and streamlined healthcare information monitoring and usage, this technology is still awaiting entry into clinical trials, urging a closer gaze within the medical community. Oligonucleotide-based biosensors, leveraging DNA or RNA’s long-term storage of information, offer great specificity and sensitivity, as described throughout this paper. Consequently, this renders them as an ideal choice for revolutionizing GC diagnosis and facilitating early intervention. The aim of this review is to provide an overview of this cutting-edge, invaluable technology and its limitations across various aspects.

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On-chip plasmonic detection of microRNA-106a in gastric cancer using hybridized gold nanoparticles

Cited by 10 publications

References 25 publications

Quantum Plasmonics: Energy Transport Through Plasmonic Gap

Quantum Plasmonics: Energy Transport Through Plasmonic Gap

A colorimetric detection of microRNA-148a in gastric cancer by gold nanoparticle–RNA conjugates

Can Nano Yield Big Insights? Oligonucleotide-Based Biosensors in Early Diagnosis of Gastric Cancer

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