On-chip temperature compensation in an integrated slot-waveguide ring resonator refractive index sensor array

Gylfason, Kristinn B.; Carlborg, Carl Fredrik; Kaźmierczak, Andrzej; Dortu, Fabian; Sohlström, Hans; Vivien, Laurent; Barrios, Carlos Angulo; Wijngaart, Wouter van der; Stemme, G.

doi:10.1364/oe.18.003226

Cited by 104 publications

(62 citation statements)

References 20 publications

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“…The results are shown in Table 1. For these values of the sensitivity, (14) implies that the relative change in the resonant wavelength is It should be noted that the gain in the sensitivity for a dual core design is not that significant in order to justify the complexity of the design and the manufacturing challenges that entails. Therefore, it is suggested that in most practical situations, the design of choice would be a single core waveguide with dimensions for the core dimensions provides better sensitivity than the dual core design as far as the behavior of the system as biosensor is considered.…”

Section: Simulations Results and Discussion Regarding Design Optimimentioning

confidence: 99%

A study on refractive index sensors based on optical micro-ring resonators

Tsigaridas

2017

Photonic Sens

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Abstract:In this work, the behavior of refractive index sensors based on optical micro-ring resonators is studied in detail. Using a result of waveguide perturbation theory in combination with numerical simulations, the optimum design parameters of the system, maximizing the sensitivity of the sensor, are determined. It is found that, when optimally designed, the sensor can detect relative refractive index changes of the order of n/n310 4 , assuming that the experimental setup can detect relative wavelength shifts of the order of /310 5. The behavior of the system as bio-sensor has also been examined. It is found that, when optimally designed, the system can detect refractive index changes of the order of n10 3 for a layer thickness of t=10 nm, and changes in the layer thickness of the order of t0.24 nm, for a refractive index change of n=0.05.

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Section: Simulations Results and Discussion Regarding Design Optimimentioning

confidence: 99%

A study on refractive index sensors based on optical micro-ring resonators

Tsigaridas

2017

Photonic Sens

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“…Sensor sensitivity can be improved by a proper slot region design, which allows for a complete filling of the slot region by the biological fluid [44]. Recent results [76] have shown that a proper slotted ring resonator design allows for eliminating sensor response temperature dependence. This is an important advantage with respect of previously proposed sensor configurations.…”

Section: Advantages Of Label-free Optical Detectionmentioning

confidence: 99%

Optical biosensors to analyze novel biomarkers in oncology

Donzella

Crea

2011

Journal of Biophotonics

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Many cancer types are characterized by poor survival and unpredictable therapy response. Easy-to-perform molecular analyses may help patient stratification and treatment tailoring. Several integrated devices have been proposed to overcome current analysis equipment limitations. They offer improved sensitivity and easy availability of parallel detection. Particularly, unlabelled optical biosensors combine the manifold advantages of integrated sensors (e.g. easy handling, portability and low-volume requirement) with detection of target molecules in their original form. Here, we review integrated optical biosensor current features, and discuss their possible application to the detection of protein variants from body fluids, with particular regard to histone modifications. Indeed, histone post-translational modifications are a set of epigenetic markers frequently deregulated in cancer. Available technology does not allow a comprehensive analysis of all histone modifications in a single patient. Thus, label-free optical biosensors may pave the way to the discovery and detection of a novel class of biomarkers in oncology.

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“…The measurements described in the next subsection were made over 7 K operating window, without external temperature control and individual sensor calibration. This is further described elsewhere [18].…”

Section: Sabio Nanophotonic Sensorsmentioning

confidence: 99%

Advances in Nanophotonic Sensing Technologies During Three International Label-Free Lab-On-Chip Projects

Hill

2011

BioNanoSci.

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We review the results from the use of various integrated nanophotonic sensors for label-free biosensing developed in three recent European biosensor collaborations: SABIO, INTOPSENS, and POSITIVE. Nanophotonic transducers are attractive for label-free biosensing due to their small footprint, high Q-factors, and compatibility with on-chip optics and microfluidics. This enables integrated sensor arrays for compact labs-on-chip. One application of label-free sensor arrays is for point-of-care medical diagnostics. Bringing such powerful tools to the single medical practitioner is an important step towards personalized medicine, but requires addressing a number of issues: improving limit of detection, managing the influence of temperature, parallelization of the measurement for higher throughput and on-chip referencing, efficient lightcoupling strategies to simplify alignment, and packaging of the nanophotonics chip and integration with microfluidics. From SABIO, we report a volume sensing sensitivity of 240 nm/RIU and detection limit of 5×10 −6 RIU, and a surface sensing limit of detection (LOD) of 0.9 pg/mm 2 for at 1.3 μm for an eight-channel slot-waveguide ring resonator sensor array, within a microfluidics integrated compact cartridge. In INTOPSENS, ongoing efforts have so far resulted in various nanophotonic transducer designs with volume sensing sensitivities as great as 2,169 nm/RIU and LODs down to 8.3×10 −6 RIU at 1.5 μm. Early experiments from the POSITIVE project have demonstrated volumetric sensitivities as high as 1,247 nm/RIU at 1.5 μm.

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On-chip temperature compensation in an integrated slot-waveguide ring resonator refractive index sensor array

Cited by 104 publications

References 20 publications

A study on refractive index sensors based on optical micro-ring resonators

A study on refractive index sensors based on optical micro-ring resonators

Optical biosensors to analyze novel biomarkers in oncology

Advances in Nanophotonic Sensing Technologies During Three International Label-Free Lab-On-Chip Projects

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