On Circadian Variation of Myocardial Reperfusion Injury

Braunwald, Eugene

doi:10.1161/circresaha.111.260265

Cited by 10 publications

(8 citation statements)

References 25 publications

(26 reference statements)

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“…A landmark study published in 1985 documented a three-fold higher incidence of myocardial infarction in the morning as compared to the late evening hours. 8 An ensuing meta-analysis with more than 60,000 patients confirmed this result, and many subsequent studies have identified circadian patterns across a broad range of cardiovascular events, including unstable angina and stent thrombosis, stroke, ventricular arrhythmia, and aortic dissection. 8 The mechanisms underlying these circadian patterns are complex and incompletely understood.…”

Section: Circadian Rhythms In the Pathogenesis Of Cardiovascular Diseasementioning

confidence: 82%

“…8 An ensuing meta-analysis with more than 60,000 patients confirmed this result, and many subsequent studies have identified circadian patterns across a broad range of cardiovascular events, including unstable angina and stent thrombosis, stroke, ventricular arrhythmia, and aortic dissection. 8 The mechanisms underlying these circadian patterns are complex and incompletely understood. What is clear, however, is that there is convincing human data for involvement of circadian-regulated proteins and hormones that likely contribute to plaque rupture and modulate myocardial response to ischemia.…”

Section: Circadian Rhythms In the Pathogenesis Of Cardiovascular Diseasementioning

confidence: 82%

“…Regulators include cortisol and other stress hormones through activation of the sympathetic nervous system and increases in platelet reactivity that contribute to thrombosis. 8 Two recent clinical studies demonstrated that in addition to peak incidence of myocardial infarction, the heart is also more vulnerable to an ischemic event in the early morning hours leading to larger infarct sizes. 9,10 …”

Section: Circadian Rhythms In the Pathogenesis Of Cardiovascular Diseasementioning

confidence: 99%

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Health Implications of Disrupted Circadian Rhythms and the Potential for Daylight as Therapy

Brainard

Gobel

Scott³

et al. 2015

Anesthesiology

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Section: Circadian Rhythms In the Pathogenesis Of Cardiovascular Diseasementioning

confidence: 82%

Section: Circadian Rhythms In the Pathogenesis Of Cardiovascular Diseasementioning

confidence: 82%

Section: Circadian Rhythms In the Pathogenesis Of Cardiovascular Diseasementioning

confidence: 99%

See 1 more Smart Citation

Health Implications of Disrupted Circadian Rhythms and the Potential for Daylight as Therapy

Brainard

Gobel

Scott³

et al. 2015

Anesthesiology

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show abstract

“…This increased morning incidence has been confirmed repeatedly in individual populations and in a meta-analysis of more than 60,000 patients. Other studies reported an increased incidence during early morning hours in unstable angina, sudden death, stroke, ventricular arrhythmias, cardiogenic shock, aortic aneurysm rupture, stent thrombosis, and transient myocardial ischemia (Braunwald, 2012). In fact, two recent studies found that patients have larger infarct sizes in early morning hours compared to other times of the day (Reiter et al, 2012; Suarez-Barrientos et al, 2011; Ibanez et al, 2012).…”

Section: Pathogenesismentioning

confidence: 99%

Cardiac Period 2 in myocardial ischemia: Clinical implications of a light dependent protein

Bonney

Hughes

Harter

et al. 2013

The International Journal of Biochemistry & Cell Biology

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Since the onset of myocardial infarction and stroke has distinct circadian patterns, the disruption of circadian rhythms may contribute to cardiovascular disease. A recent clinical study, reporting that the severity of myocardial ischemia depends on the time-of-day when ischemia occurs, highlights the impact of circadian rhythms on cardiovascular disease. In support of these observations, we found a cardioprotective role of the circadian rhythm protein Period 2 (Per2) during myocardial ischemia in mice. In these studies, exposing mice to daylight induced cardiac Per2, which was associated with protection from myocardial ischemia. Recent epidemiological studies found sunlight to be the dominant regulator of the human circadian rhythm, suggesting sunlight cycles are critical for maintaining a healthy cardiovascular system. However, the impact of circadian rhythm proteins on human disease remains unclear. This current review aims to make a link to current and future clinical practice by targeting cardiac Per2.

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“…This increased morning incidence has been confirmed repeatedly in individual populations and in a meta-analysis of more than 60,000 patients. Other studies reported an increased incidence during early morning hours in unstable angina, for sudden death, stroke, ventricular arrhythmias, cardiogenic shock, aortic aneurysm rupture, stent thrombosis, and transient myocardial ischemia [64]. In fact, two recent studies even found that patients have larger infarct sizes in the early morning hours compared to other times of the day [65–67].…”

Section: The Impact Of Circadian Rhythmes On Infarct Sizementioning

confidence: 99%

Anesthetic Cardioprotection: The Role of Adenosine

Bonney¹,

Hughes²,

Eckle

2014

CPD

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Brief periods of cardiac ischemia and reperfusion exert a protective effect against subsequent longer ischemic periods, a phenomenon coined ischemic preconditioning. Similar, repeated brief episodes of coronary occlusion and reperfusion at the onset of reperfusion, called postconditioning, dramatically reduce infarct sizes. Interestingly, both effects can be achieved by the administration of any volatile anesthetic. In fact, cardio-protection by volatile anesthetics is an older phenomenon than ischemic pre-or post-conditioning. Although the mechanism through which anesthetics can mimic ischemic pre-or post-conditioning is still unknown, adenosine generation and signaling are the most redundant triggers in ischemic pre-or postconditioning. In fact, adenosine signaling has been implicated in isoflurane-mediated cardioprotection. Adenosine acts via four receptors designated as A1, A2a, A2b, and A3. Cardioprotection has been associated with all subtypes, although the role of each remains controversial. Much of the controversy stems from the abundance of receptor agonists and antagonists that are, in fact, capable of interacting with multiple receptor subtypes. Recently, more specific receptor agonists and new genetic animal models have become available paving way towards new discoveries. As such, the adenosine A2b receptor was shown to be the only 1 of the adenosine receptors whose cardiac expression is induced by ischemia in both mice and humans and whose function is implicated in ischemic preor post-conditioning. In the current review, we will focus on adenosine signaling in the context of anesthetic cardioprotection and will highlight new discoveries, which could lead to new therapeutic concepts to treat myocardial ischemia using anesthetic preconditioning.

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On Circadian Variation of Myocardial Reperfusion Injury

Cited by 10 publications

References 25 publications

Health Implications of Disrupted Circadian Rhythms and the Potential for Daylight as Therapy

Health Implications of Disrupted Circadian Rhythms and the Potential for Daylight as Therapy

Cardiac Period 2 in myocardial ischemia: Clinical implications of a light dependent protein

Anesthetic Cardioprotection: The Role of Adenosine

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