On-column refolding and purification of recombinant human interleukin-1 receptor antagonist (rHuIL-1ra) expressed as inclusion body in Escherichia coli

Tan, Haidong; Dan, Guoping; Gong, Huiying; Cao, Lijun

doi:10.1007/s10529-006-9306-1

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2015

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“…It has long been reported that IBs are formed with unfolded or misfolded polypeptides that are devoid of biological activity [9,10]. Hence, the occurrence of IBs is deemed to be problematic in a biotechnological context, which results in major economic impacts particularly when protein refolding from inclusion bodies becomes necessary [3,8,9,11].…”

Section: Introductionmentioning

confidence: 99%

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Improved Refolding Efficacy of Recombinant Human Interferon α-2b via pH Modulation

Dashbolaghi¹,

Khatami²,

Sardari³

et al. 2015

Trop. J. Pharm Res

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Section: Introductionmentioning

confidence: 99%

“…Hence, the occurrence of IBs is deemed to be problematic in a biotechnological context, which results in major economic impacts particularly when protein refolding from inclusion bodies becomes necessary [3,8,9,11]. The formation of IBs is usually the consequence of the rapid accumulation of newly synthesized polypeptides [4,12].…”

Section: Introductionmentioning

confidence: 99%