On Coumarins from the Fruits of Angelica pubescens MAXIM.

Angelica spp.

“…Ligustilide (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) Angelicide (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) [18], a ligustilide dimer, was also isolated from the roots of A. sinensis and structurally elucidated.…”

“…Angelicide (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) Additional nonvolatile constituents were identified as brefeldin A (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), 6methoxy-7-hydroxy-coumarin, fJ-sitosterol, stigmasterol, and fJ-sitosterol-D-glucoside [19]. From the essential oil of the leaves a number of terpene compounds such as a-pinene, myrcene, limonene, verbenone, copaene, fJ-farnesene, fJ-selinene, and fJand a-cadinene were detected [20].…”

“…Hata and Kozawa have reported the isolation of osthol (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31), bergapten, glabralactone (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), and angelol, from the root of A. pubescens [23]. pubescens contains a number of coumarin and furocoumarin derivatives, some of which were also found in A. dahurica.…”

“…pubescens contains a number of coumarin and furocoumarin derivatives, some of which were also found in A. dahurica. (17-33) 5-Isopentenyloxy-7-methoxy-8-senecioyl-coumarin (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) The structure of angelol (angelol A) was the focus of several studies [23,25,26]. Kozawa et al have also reported isolation of psoralen, xanthotoxin, isopimpinellin (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33), byakangelicin, coumurrayin (17-34), 7-methoxy-8-senecioylcoumarin, scopoletin, and two prenylcoumarins structurally elucidated as 8-(3-hydroxyisovaleroyl)-5, 7 -dimethoxycoumarin and 5-isopentenyloxy-7 -methoxy-8-senecioylcoumarin (17)(18)(19)(20)(21)…”

“…(17-33) 5-Isopentenyloxy-7-methoxy-8-senecioyl-coumarin (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) The structure of angelol (angelol A) was the focus of several studies [23,25,26]. From the fruits of A. pubescens, nine coumarins were isolated and identified as osthol, byakangelicin, byakangelicol, oxypeucedanin, umbelliferone, umbelliprenin , imperatorin, neobyakangelicol, and sec-O-acetylbyakangelicin (17)(18)(19) [29]. The structures of these compounds were determined on the basis of spectral and chemical evidence.…”